Gene therapy sculpts the bone
Luigi D. Notarangelo
p.5067-5068
What if conventional-dose imatinib fails?
Charles A. Schiffer
p.5068-5069
Platelet tissue factor comes of age
Andrew S. Weyrich, Hansjörg Schwertz, and Nigel Mackman
p.5069-5070
Antitumor T-cell wars: do CD4s outwit CD8s?
Ignacio Melero
p.5070-5071
MicroRNAs play a role in neoplasia
Thomas J. Kipps
p.5071-5072
To transmigrate or not to transmigrate
Klaus Ley
p.5072-5073
Uncontrolled Wnt signaling causes leukemia
Frank J. T. Staal
p.5073-5074
Scavenger receptor helps erythroblasts stay on island
Mark J. Koury
p.5074-5075
Clinical proteomics: towards diagnostics and prognostics
Visith Thongboonkerd
p.5075-5076
Monocytes TIE(2)d up in murky business
George Coukos
p.5076
To code or not to code
Anna Rita Migliaccio
p.5077-5078
PLENARY PAPERS:
Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice
Elizabeth S. Raveche, Erica Salerno, Brian J. Scaglione, Vijaya Manohar, Fatima Abbasi, Yi-Chu Lin, Torgny Fredrickson, Pablo Landgraf, Sumant Ramachandra, Konrad Huppi, Jorge R. Toro, Vincent E. Zenger, Robert A. Metcalf, and Gerald E. Marti
p.5079-5086
REVIEW ARTICLES:
The growing complexity of platelet aggregation
Shaun P. Jackson
p.5087-5095
REVIEW IN TRANSLATIONAL HEMATOLOGY:
Waldenström macroglobulinemia
Arun Vijay and Morie A. Gertz
p.5096-5103
HOW I TREAT:
How I treat patients with polycythemia vera
Guido Finazzi and Tiziano Barbui
p.5104-5111
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-B activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis
Ajaikumar B. Kunnumakkara, Asha S. Nair, Kwang Seok Ahn, Manoj K. Pandey, Zhengfang Yi, Mingyao Liu, and Bharat B. Aggarwal
p.5112-5121
The adaptor protein Lad associates with the G protein ß subunit and mediates chemokine-dependent T-cell migration
Dongsu Park, Inyoung Park, Deogwon Lee, Young Bong Choi, Hyunsook Lee, and Yungdae Yun
p.5122-5128
CLINICAL TRIALS AND OBSERVATIONS:
Postremission treatment of elderly patients with acute myeloid leukemia in first complete remission after intensive induction chemotherapy:results of the multicenter randomized Acute Leukemia French Association (ALFA) 9803 trial
Claude Gardin, Pascal Turlure, Thierry Fagot, Xavier Thomas, Christine Terre, Nathalie Contentin, Emmanuel Raffoux, Stephane de Botton, Cecile Pautas, Oumedaly Reman, Jean-Henri Bourhis, Pierre Fenaux, Sylvie Castaigne, Mauricette Michallet, Claude Preudhomme, Thierry de Revel, Dominique Bordessoule, and Herve Dombret, for the Acute Leukemia French Association (ALFA)
p.5129-5135
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
Daniel J. DeAngelo, Daohai Yu, Jeffrey L. Johnson, Steven E. Coutre, Richard M. Stone, Alison T. Stopeck, Jon P. Gockerman, Beverly S. Mitchell, Frederick R. Appelbaum, and Richard A. Larson
p.5136-5142
Dasatinib or high-dose imatinib for chronic-phase chronic myeloid leukemia after failure of first-line imatinib: a randomized phase 2 trial
Hagop Kantarjian, Ricardo Pasquini, Nelson Hamerschlak, Philippe Rousselot, Jerzy Holowiecki, Saengsuree Jootar, Tadeusz Robak, Nina Khoroshko, Tamas Masszi, Aleksander Skotnicki, Andrzej Hellmann, Andrey Zaritsky, Anatoly Golenkov, Jerald Radich, Timothy Hughes, Athena Countouriotis, and Neil Shah
p.5143-5150
A phase 2 study of the oral farnesyltransferase inhibitor tipifarnib in patients with refractory or relapsed acute myeloid leukemia
Jean-Luc Harousseau, Jeffrey E. Lancet, Josy Reiffers, Bob Lowenberg, Xavier Thomas, Francoise Huguet, Pierre Fenaux, Steven Zhang, Wayne Rackoff, Peter De Porre, and Richard Stone, for the Farnesyltransferase Inhibition Global Human Trials (FIGHT) Acute Myeloid Leukemia Study Group
p.5151-5156
Brief report Fatal agranulocytosis after deferiprone therapy in a child with Diamond-Blackfan anemia
Jan-Inge Henter and Jonas Karlén
p.5157-5159
Brief report A novel proteoliposomal vaccine induces antitumor immunity against follicular lymphoma
Sattva S. Neelapu, Barry L. Gause, Linda Harvey, Seung-Tae Lee, Andrea Robin Frye, Jessie Horton, Richard J. Robb, Mircea C. Popescu, and Larry W. Kwak
p.5160-5163
Brief report Long-term disease-free survivors with cytogenetically normal acute myeloid leukemia and MLL partial tandem duplication: a Cancer and Leukemia Group B study
Susan P. Whitman, Amy S. Ruppert, Guido Marcucci, Krzysztof Mrózek, Peter Paschka, Christian Langer, Claudia D. Baldus, Jing Wen, Tamara Vukosavljevic, Bayard L. Powell, Andrew J. Carroll, Jonathan E. Kolitz, Richard A. Larson, Michael A. Caligiuri, and Clara D. Bloomfield
p.5164-5167
GENE THERAPY:
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene
Cary Hsu, Stephanie A. Jones, Cyrille J. Cohen, Zhili Zheng, Keith Kerstann, Juhua Zhou, Paul F. Robbins, Peter D. Peng, Xinglei Shen, Theotonius J. Gomes, Cynthia E. Dunbar, David J. Munroe, Claudia Stewart, Kenneth Cornetta, Danny Wangsa, Thomas Ried, Steven A. Rosenberg, and Richard A. Morgan
p.5168-5177
Hematopoietic stem cell–targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice
Maria K. Johansson, Teun J. de Vries, Ton Schoenmaker, Mats Ehinger, Ann C. M. Brun, Anders Fasth, Stefan Karlsson, Vincent Everts, and Johan Richter
p.5178-5185
HEMATOPOIESIS:
Studies of c-Mpl function distinguish the replication of hematopoietic stem cells from the expansion of differentiating clones
Janis L. Abkowitz and Jing Chen
p.5186-5190
EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression
Lori A. Wagner, Clarissa J. Christensen, Diane M. Dunn, Gerald J. Spangrude, Ann Georgelas, Linda Kelley, M. Sean Esplin, Robert B. Weiss, and Gerald J. Gleich
p.5191-5198
Cyclin D–Cdk4 is regulated by GATA-1 and required for megakaryocyte growth and polyploidization
Andrew G. Muntean, Liyan Pang, Mortimer Poncz, Steven F. Dowdy, Gerd A. Blobel, and John D. Crispino
p.5199-5207
Migratory path of definitive hematopoietic stem/progenitor cells during zebrafish development
Hao Jin, Jin Xu, and Zilong Wen
p.5208-5214
ß-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation
Laure Meyer, Bénédicte Deau, Hana Forejtníková, Dominique Duménil, Florence Margottin-Goguet, Catherine Lacombe, Patrick Mayeux, and Frédérique Verdier
p.5215-5222
The macrophage CD163 surface glycoprotein is an erythroblast adhesion receptor
Babs O. Fabriek, Machteld M. J. Polfliet, Rianka P. M. Vloet, Roel C. van der Schors, Antoon J. M. Ligtenberg, Lehn K. Weaver, Christiaan Geest, Kenjiro Matsuno, Søren K. Moestrup, Christien D. Dijkstra, and Timo K. van den Berg
p.5223-5229
Brief report Friend of GATA-1–independent transcriptional repression: a novel mode of GATA-1 function
Kirby D. Johnson, Meghan E. Boyer, Jeong-Ah Kang, Amittha Wickrema, Alan B. Cantor, and Emery H. Bresnick
p.5230-5233
Brief report Perforin gene mutations in patients with acquired aplastic anemia
Elena E. Solomou, Federica Gibellini, Brian Stewart, Daniela Malide, Maria Berg, Valeria Visconte, Spencer Green, Richard Childs, Stephen J. Chanock, and Neal S. Young
p.5234-5237
Brief report Expression of oncogenic K-ras from its endogenous promoter leads to a partial block of erythroid differentiation and hyperactivation of cytokine-dependent signaling pathways
Jing Zhang, Yangang Liu, Caroline Beard, David A. Tuveson, Rudolf Jaenisch, Tyler E. Jacks, and Harvey F. Lodish
p.5238-5241
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
Human platelets synthesize and express functional tissue factor
Olga Panes, Valeria Matus, Claudia G. Sáez, Teresa Quiroga, Jaime Pereira, and Diego Mezzano
p.5242-5250
Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia
Jasimuddin Ahamed, Frank Niessen, Toru Kurokawa, Young Kyung Lee, Gourab Bhattacharjee, James H. Morrissey, and Wolfram Ruf
p.5251-5259
Ligand density dramatically affects integrin IIbß3-mediated platelet signaling and spreading
Markéta Jirousková, Jyoti K. Jaiswal, and Barry S. Coller
p.5260-5269
Fatal hemorrhage in mice lacking -glutamyl carboxylase
Aihua Zhu, Hongmin Sun, Richard M. Raymond, Jr, Barbara C. Furie, Bruce Furie, Mila Bronstein, Randal J. Kaufman, Randal Westrick, and David Ginsburg
p.5270-5275
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer
Mary Anna Venneri, Michele De Palma, Maurilio Ponzoni, Ferdinando Pucci, Cristina Scielzo, Erika Zonari, Roberta Mazzieri, Claudio Doglioni, and Luigi Naldini
p.5276-5285
The effect of a single nucleotide polymorphism on human 2-antiplasmin activity
Victoria J. Christiansen, Kenneth W. Jackson, Kyung N. Lee, and Patrick A. McKee
p.5286-5292
IMMUNOBIOLOGY:
Human tissue mast cells are an inducible reservoir of persistent HIV infection
J. Bruce Sundstrom, Jane E. Ellis, Gregory A. Hair, Arnold S. Kirshenbaum, Dean D. Metcalfe, Hong Yi, Adriana C. Cardona, Michael K. Lindsay, and Aftab A. Ansari
p.5293-5300
Resistance to TGF-ß1 correlates with aberrant expression of TGF-ß receptor II in human B-cell lymphoma cell lines
Gang Chen, Paritosh Ghosh, Hiroshi Osawa, Carl Y. Sasaki, Louis Rezanka, Jiandong Yang, Thomas J. O'Farrell, and Dan L. Longo
p.5301-5307
Roles of RabGEF1/Rabex-5 domains in regulating FcRI surface expression and FcRI-dependent responses in mast cells
Janet Kalesnikoff, Eon J. Rios, Ching-Cheng Chen, M. Alejandro Barbieri, Mindy Tsai, See-Ying Tam, and Stephen J. Galli
p.5308-5317
TLR3 ligand stimulates fully functional memory CD8+ T cells in the absence of CD4+ T-cell help
Sandra Hervas-Stubbs, Aurélie Olivier, Florence Boisgerault, Nathalie Thieblemont, and Claude Leclerc
p.5318-5326
A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo
M. Gabriele Bixel, Björn Petri, Alexander G. Khandoga, Andrej Khandoga, Karen Wolburg-Buchholz, Hartwig Wolburg, Sigrid März, Fritz Krombach, and Dietmar Vestweber
p.5327-5336
The DC-SIGN–related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells
Angeles Dominguez-Soto, Laura Aragoneses-Fenoll, Enrique Martin-Gayo, Lorena Martinez-Prats, Maria Colmenares, Marisa Naranjo-Gomez, Francesc E. Borras, Pilar Munoz, Mercedes Zubiaur, Maria L. Toribio, Rafael Delgado, and Angel L. Corbi
p.5337-5345
CD4 cells can be more efficient at tumor rejection than CD8 cells
Ainhoa Perez-Diez, Nathalie T. Joncker, Kyungho Choi, William F. N. Chan, Colin C. Anderson, Olivier Lantz, and Polly Matzinger
p.5346-5354
IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation
Lucie Baudino, Liliane Fossati-Jimack, Christelle Chevalley, Eduardo Martinez-Soria, Marc J. Shulman, and Shozo Izui
p.5355-5362
Kit is essential for PMA-inflammation–induced mast-cell accumulation in the skin
Claudia Waskow, Susanne Bartels, Susan M. Schlenner, Celine Costa, and Hans-Reimer Rodewald
p.5363-5370
Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets
Diego Piccioli, Simona Tavarini, Erica Borgogni, Veronica Steri, Sandra Nuti, Chiara Sammicheli, Monia Bardelli, Daniela Montagna, Franco Locatelli, and Andreas Wack
p.5371-5379
Naturally occurring C-terminally truncated STAT5 is a negative regulator of HIV-1 expression
Andrea Crotti, Marina Lusic, Rossella Lupo, Patricia M. J. Lievens, Elio Liboi, Giulia Della Chiara, Marco Tinelli, Adriano Lazzarin, Bruce K. Patterson, Mauro Giacca, Chiara Bovolenta, and Guido Poli
p.5380-5389
CD38/CD19: a lipid raft–dependent signaling complex in human B cells
Silvia Deaglio, Tiziana Vaisitti, Richard Billington, Luciana Bergui, Paola Omede', Armando A. Genazzani, and Fabio Malavasi
p.5390-5398
Direct inhibition of CD40L expression can contribute to the clinical efficacy of daclizumab independently of its effects on cell division and Th1/Th2 cytokine production
James T. Snyder, Jijia Shen, Hooman Azmi, Jeannie Hou, Daniel H. Fowler, and Jack A. Ragheb
p.5399-5406
Brief report A novel proteoliposomal vaccine elicits potent antitumor immunity in mice
Mircea C. Popescu, Richard J. Robb, Michael M. Batenjany, Lawrence T. Boni, Mary E. Neville, Robin W. Pennington, Sattva S. Neelapu, and Larry W. Kwak
p.5407-5410
NEOPLASIA:
Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells
Hardik Modi, Tinisha McDonald, Su Chu, Jiing-Kuan Yee, Stephen J. Forman, and Ravi Bhatia
p.5411-5421
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis
Magda Pinyol, Silvia Bea, Laura Plà, Vincent Ribrag, Jacques Bosq, Andreas Rosenwald, Elias Campo, and Pedro Jares
p.5422-5429
Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
Suzanne Trudel, Zhi Hua Li, Jennifer Rauw, Rodger E. Tiedemann, Xiao Yan Wen, and A. Keith Stewart
p.5430-5438
Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival
James R. Cerhan, Sophia Wang, Matthew J. Maurer, Stephen M. Ansell, Susan M. Geyer, Wendy Cozen, Lindsay M. Morton, Scott Davis, Richard K. Severson, Nathaniel Rothman, Charles F. Lynch, Sholom Wacholder, Stephen J. Chanock, Thomas M. Habermann, and Patricia Hartge
p.5439-5446
Hsp72 up-regulates Epstein-Barr virus EBNALP coactivation with EBNA2
Chih-Wen Peng, Bo Zhao, Hong-Chi Chen, Min-Luen Chou, Chiou-Yan Lai, Shinn-Zong Lin, Hsue-Yin Hsu, and Elliott Kieff
p.5447-5454
Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways
Michael Wang, Liang Zhang, Xiaohong Han, Jing Yang, Jianfei Qian, Sungyoul Hong, Felipe Samaniego, Jorge Romaguera, and Qing Yi
p.5455-5462
ß-Catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation
Zhuyan Guo, Marei Dose, Damian Kovalovsky, Rui Chang, Jennifer O'Neil, A. Thomas Look, Harald von Boehmer, Khashayarsha Khazaie, and Fotini Gounari
p.5463-5472
Brief report ERK1/2 phosphorylation is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia
Chiara Gregorj, Maria R. Ricciardi, Maria T. Petrucci, Maria C. Scerpa, Fabiana De Cave, Paola Fazi, Marco Vignetti, Antonella Vitale, Marco Mancini, Giuseppe Cimino, Salvatore Palmieri, Francesco Di Raimondo, Giorgina Specchia, Francesco Fabbiano, Nicola Cantore, Federico Mosna, Andrea Camera, Mario Luppi, Luciana Annino, Eustachio Miraglia, Giuseppe Fioritoni, Francesca Ronco, Giovanna Meloni, Franco Mandelli, Michael Andreeff, Michele Milella, Robin Foà, and Agostino Tafuri, the GIMEMA Acute Leukemia Working Party, Italy
p.5473-5476
Brief report Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations
Kazuyuki Matsuda, Akira Shimada, Nao Yoshida, Atsushi Ogawa, Akihiro Watanabe, Shuhei Yajima, Susumu Iizuka, Kazutoshi Koike, Fumio Yanai, Keiichiro Kawasaki, Masakatsu Yanagimachi, Akira Kikuchi, Yoshitoshi Ohtsuka, Eiko Hidaka, Kazuyoshi Yamauchi, Miyuki Tanaka, Ryu Yanagisawa, Yozo Nakazawa, Masaaki Shiohara, Atsushi Manabe, Seiji Kojima, and Kenichi Koike
p.5477-5480
RED CELLS:
Dynamic regulation of Gata factor levels is more important than their identity
Rita Ferreira, Albert Wai, Ritsuko Shimizu, Nynke Gillemans, Robbert Rottier, Marieke von Lindern, Kinuko Ohneda, Frank Grosveld, Masayuki Yamamoto, and Sjaak Philipsen
p.5481-5490
Brief report A complex splicing defect associated with homozygous ankyrin-deficient hereditary spherocytosis
E. Jennifer Edelman, Yelena Maksimova, Feride Duru, Cigdem Altay, and Patrick G. Gallagher
p.5491-5493
STEM CELLS IN HEMATOLOGY:
Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins
Julia Beckmann, Sebastian Scheitza, Peter Wernet, Johannes C. Fischer, and Bernd Giebel
p.5494-5501
TRANSPLANTATION:
Homeostatic expansion and repertoire regeneration of donor T cells during graft versus host disease is constrained by the host environment
Jack Gorski, Xiao Chen, Mariya Gendelman, Maryam Yassai, Ashley Krueger, Elizabeth Tivol, Brent Logan, Richard Komorowski, Sanja Vodanovic-Jankovic, and William R. Drobyski
p.5502-5510
Proteomic patterns predict acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Eva M. Weissinger, Eric Schiffer, Bernd Hertenstein, James L. Ferrara, Ernst Holler, Michael Stadler, Hans-Jochem Kolb, Axel Zander, Petra Zürbig, Markus Kellmann, and Arnold Ganser
p.5511-5519
CORRESPONDENCE:
Vitamin supplementation in the secondary prevention of venous thromboembolism: about the VITRO study
Rossella Marcucci, Francesco Sofi, Anna Maria Gori, Gian Franco Gensini, and Rosanna Abbate
p.5520
Vitamins and Thrombosis (VITRO) study—homocysteine lowering with B vitamins
Antonis Georg Tsamaloukas
p.5520-5521
Response: Homocysteine lowering and recurrent venous thrombosis: the VITRO trial
Martin den Heijer, Henk J. Blom, Frits R. Rosendaal, and Gerard M. J. Bos
p.5521-5522
RAG1 and BRCA2 polymorphisms in non-Hodgkin lymphoma
Kathryn Scott, Peter J. Adamson, Sharon L. Barrans, Lisa J. Worrillow, Eleanor V. Willett, and James M. Allan
p.5522-5523
NHL and genomic variability in RAG1 and BRCA2
Deirdre A. Hill, Sophia Wang, Patricia Hartge, and Nathaniel Rothman
p.5523
Targeting host B-cell immune responses by persistent donor NK-cell alloreactivity following nonmyeloablative allogeneic stem cell transplantation
Roelof Flierman, Geert Westerhuis, Marjolijn Hameetman, Leonie M. van Duivenvoorde, Thorbald van Hall, Jacob M. van Laar, Willem E. Fibbe, and René E. M. Toes
p.5524-5525
Effect of the new HJV-L165X mutation on penetrance of HFE
Boukje A. C. van Dijk, Erwin H. J. M. Kemna, Harold Tjalsma, Siem M. Klaver, Erwin T. G. Wiegerinck, Jan-Pieter Goossens, Peter H. Th. J. Slee, Martijn H. Breuning, and Dorine W. Swinkels
p.5525-5526
A closer look at intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)
Michael D. Tarantino, James B. Bussel, Douglas B. Cines, Keith R. McCrae, Terry Gernsheimer, Howard A. Liebman, Wing-Yen Wong, Roshni Kulkarni, Eric Grabowski, and Robert McMillan
p.5527
Response: Further examination of intravascular hemolysis (IVH) following intravenous anti-D for immune thrombocytopenic purpura (ITP)
Ann Reed Gaines
p.5528
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