NAVEGADOR SBHH

INSIDE BLOOD:

AML1/ETO, a promiscuous fusion oncoprotein
Kevin Petrie and Arthur Zelent
p.4109-4110
Dasatinib in accelerated phase
Stephen O'Brien
p.4110
Flow beats inflammation, but not always
Bernd R. Binder
p.4111-4112
"Stimulate the phagocytes!" Fascin-ating! Are DCs actin' up?
Philip L. McCarthy
p.4112-4113
PECAMigration
Peter J. Newman
p.4113-4114
Crypt cell hypothesis: technical knock-out
Robert E. Fleming
p.4114-4115
Of mice and iron: ferroportin disease
Nancy C. Andrews
p.4115
Looking at HIV-infected lymph nodes
Zvi Grossman
p.4116-4117
At last, an "ointment" for gastrointestinal GVHD?
Alois Gratwohl
p.4117
Inflamed endothelium: an EPC adhesion kit
Elaine W. Raines
p.4118
HOW I TREAT:
How I treat refractory acute GVHD
H. Joachim Deeg
p.4119-4126
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion
Laura Lasagni, Renaud Grepin, Benedetta Mazzinghi, Elena Lazzeri, Claudia Meini, Costanza Sagrinati, Francesco Liotta, Francesca Frosali, Elisa Ronconi, Nathalie Alain-Courtois, Lara Ballerini, Giuseppe Stefano Netti, Enrico Maggi, Francesco Annunziato, Mario Serio, Sergio Romagnani, Andreas Bikfalvi, and Paola Romagnani
p.4127-4134
The molecular basis of IL-21–mediated proliferation
Rong Zeng, Rosanne Spolski, Esther Casas, Wei Zhu, David E. Levy, and Warren J. Leonard
p.4135-4142
CLINICAL TRIALS AND OBSERVATIONS:
Dasatinib induces significant hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in accelerated phase
Francois Guilhot, Jane Apperley, Dong-Wook Kim, Eduardo O. Bullorsky, Michele Baccarani, Gail J. Roboz, Sergio Amadori, Carmino A. de Souza, Jeffrey H. Lipton, Andreas Hochhaus, Dominik Heim, Richard A. Larson, Susan Branford, Martin C. Muller, Prasheen Agarwal, Ashwin Gollerkeri, and Moshe Talpaz
p.4143-4150
Ancestry and pharmacogenetics of antileukemic drug toxicity
Shinji Kishi, Cheng Cheng, Deborah French, Deqing Pei, Soma Das, Edwin H. Cook, Nobuko Hijiya, Carmelo Rizzari, Gary L. Rosner, Tony Frudakis, Ching-Hon Pui, William E. Evans, and Mary V. Relling
p.4151-4157
A multicenter phase 2 study of the farnesyltransferase inhibitor tipifarnib in intermediate- to high-risk myelodysplastic syndrome
Pierre Fenaux, Azra Raza, Ghulam J. Mufti, Carlo Aul, Ulrich Germing, Hagop Kantarjian, Larry Cripe, René Kerstens, Peter De Porre, and Razelle Kurzrock
p.4158-4163
Brief report  Effective asparagine depletion with pegylated asparaginase results in improved outcomes in adult acute lymphoblastic leukemia: Cancer and Leukemia Group B Study 9511
Meir Wetzler, Ben L. Sanford, Joanne Kurtzberg, Divino DeOliveira, Stanley R. Frankel, Bayard L. Powell, Jonathan E. Kolitz, Clara D. Bloomfield, and Richard A. Larson
p.4164-4167
Brief report  CD33 expression and P-glycoprotein–mediated drug efflux inversely correlate and predict clinical outcome in patients with acute myeloid leukemia treated with gemtuzumab ozogamicin monotherapy
Roland B. Walter, Ted A. Gooley, Vincent H. J. van der Velden, Michael R. Loken, Jacques J. M. van Dongen, David A. Flowers, Irwin D. Bernstein, and Frederick R. Appelbaum
p.4168-4170
Brief report  Rapid infusion rituximab in combination with corticosteroid-containing chemotherapy or as maintenance therapy is well tolerated and can safely be delivered in the community setting
Laurie H. Sehn, Jane Donaldson, Allison Filewich, Catherine Fitzgerald, Karamjit K. Gill, Nancy Runzer, Barb Searle, Sheila Souliere, John J. Spinelli, Judy Sutherland, and Joseph M. Connors
p.4171-4173
HEMATOPOIESIS:
The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease
Irene E. Zohn, Ivana De Domenico, Andrew Pollock, Diane McVey Ward, Jessica F. Goodman, Xiayun Liang, Amaru J. Sanchez, Lee Niswander, and Jerry Kaplan
p.4174-4180
Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C/EBP gene
Arati Khanna-Gupta, Hong Sun, Theresa Zibello, Han Myung Lee, Richard Dahl, Laurence A. Boxer, and Nancy Berliner
p.4181-4190
B-cell development fails in the absence of the Pbx1 proto-oncogene
Mrinmoy Sanyal, James W. Tung, Holger Karsunky, Hong Zeng, Licia Selleri, Irving L. Weissman, Leonore A. Herzenberg, and Michael L. Cleary
p.4191-4199
Cell-cycle–dependent oscillation of GATA2 expression in hematopoietic cells
Shinichiro Koga, Nobuhiro Yamaguchi, Tomoko Abe, Masayoshi Minegishi, Shigeru Tsuchiya, Masayuki Yamamoto, and Naoko Minegishi
p.4200-4208
Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway
Alexey M. Chumakov, Agnes Silla, Elizabeth A. Williamson, and H. Phillip Koeffler
p.4209-4219
TC-PTP–deficient bone marrow stromal cells fail to support normal B lymphopoiesis due to abnormal secretion of interferon-
Annie Bourdeau, Nadia Dubé, Krista M. Heinonen, Jean-François Théberge, Karen M. Doody, and Michel L. Tremblay
p.4220-4228
Proplatelet formation is regulated by the Rho/ROCK pathway
Yunhua Chang, Frédéric Auradé, Frédéric Larbret, Yanyan Zhang, Jean-Pierre Le Couedic, Laurence Momeux, Jerôme Larghero, Jacques Bertoglio, Fawzia Louache, Elisabeth Cramer, William Vainchenker, and Najet Debili
p.4229-4236
A novel role for PECAM-1 in megakaryocytokinesis and recovery of platelet counts in thrombocytopenic mice
Tarvinder S. Dhanjal, Caroline Pendaries, Ewan A. Ross, Mark K. Larson, Majd B. Protty, Chris D. Buckley, and Steve P. Watson
p.4237-4244
Human bone marrow mesenchymal stromal cells express the neural ganglioside GD2: a novel surface marker for the identification of MSCs
Caridad Martinez, Ted J. Hofmann, Roberta Marino, Massimo Dominici, and Edwin M. Horwitz
p.4245-4248
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
Prolonged shear stress and KLF2 suppress constitutive proinflammatory transcription through inhibition of ATF2
Joost O. Fledderus, Johannes V. van Thienen, Reinier A. Boon, Rob J. Dekker, Jakub Rohlena, Oscar L. Volger, Ann-Pascale J. J. Bijnens, Mat J. A. P. Daemen, Johan Kuiper, Theo J. C. van Berkel, Hans Pannekoek, and Anton J. G. Horrevoets
p.4249-4257
Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis
Javier Corral, David Hernandez-Espinosa, Jose Manual Soria, Rocio Gonzalez-Conejero, Adriana Ordonez, Jose Ramon Gonzalez-Porras, Elena Perez-Ceballos, Ramon Lecumberri, Ignacio Sanchez, Vanessa Roldan, Jose Mateo, Antonia Minano, Marcos Gonzalez, Ignacio Alberca, Jordi Fontcuberta, and Vicente Vicente
p.4258-4263
C-KIT, by interacting with the membrane-bound ligand, recruits endothelial progenitor cells to inflamed endothelium
Patrizia Dentelli, Arturo Rosso, Antonina Balsamo, Sofia Colmenares Benedetto, Annarita Zeoli, Marco Pegoraro, Giovanni Camussi, Luigi Pegoraro, and Maria Felice Brizzi
p.4264-4271
IMMUNOBIOLOGY:
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1
Angélique Biancotto, Jean-Charles Grivel, Sarah J. Iglehart, Christophe Vanpouille, Andrea Lisco, Scott F. Sieg, Robert Debernardo, Kristen Garate, Benigno Rodriguez, Leonid B. Margolis, and Michael M. Lederman
p.4272-4279
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
Mai Zhang, Takashi Angata, Jae Youn Cho, Marina Miller, David H. Broide, and Ajit Varki
p.4280-4287
Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin
René Geyeregger, Maximilian Zeyda, Wolfgang Bauer, Ernst Kriehuber, Marcus D. Säemann, Gerhard J. Zlabinger, Dieter Maurer, and Thomas M. Stulnig
p.4288-4295
Distinctive NK-cell receptor repertoires sustain high-level constitutive NK-cell activation in HIV-exposed uninfected individuals
Sophie Ravet, Daniel Scott-Algara, Elodie Bonnet, Hung Khiem Tran, Ton Tran, Ngai Nguyen, Lien Xuan Truong, Ioannis Theodorou, Françoise Barré-Sinoussi, Gianfranco Pancino, and Pascale Paul
p.4296-4305
NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome
Roi Gazit, Memet Aker, Moran Elboim, Hagit Achdout, Gil Katz, Dana G. Wolf, Shulamit Katzav, and Ofer Mandelboim
p.4306-4312
Macrophage glucocorticoid receptors regulate Toll-like receptor 4–mediated inflammatory responses by selective inhibition of p38 MAP kinase
Sandip Bhattacharyya, Diane E. Brown, Judson A. Brewer, Sherri K. Vogt, and Louis J. Muglia
p.4313-4319
DC-HIL is a negative regulator of T lymphocyte activation
Jin-Sung Chung, Kota Sato, Irene I. Dougherty, Ponciano D. Cruz, Jr, and Kiyoshi Ariizumi
p.4320-4327
TCRdimlymphocytes define populations of circulating effector cells that migrate to inflamed tissues
Zhuoli Zhang, Claire L. Gorman, Anna-Chiara Vermi, Claudia Monaco, Andrew Foey, Sally Owen, Parisa Amjadi, Alena Vallance, Catherine McClinton, Federica Marelli-Berg, Pia Isomäki, Andrew Russell, Francesco Dazzi, Timothy J. Vyse, Fionula M. Brennan, and Andrew P. Cope
p.4328-4335
Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host
Cunren Liu, Shaohua Yu, John Kappes, Jianhua Wang, William E. Grizzle, Kurt R. Zinn, and Huang-Ge Zhang
p.4336-4342
GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells
Umberto De Fanis, Francesca Mori, Rebecca J. Kurnat, Won Kyung Lee, Maria Bova, N. Franklin Adkinson, and Vincenzo Casolaro
p.4343-4350
Activation of MAP kinase p38 is critical for the cell-cycle–controlled suppressor function of regulatory T cells
Henric S. Adler, Sebastian Kubsch, Edith Graulich, Stephan Ludwig, Juergen Knop, and Kerstin Steinbrink
p.4351-4359
Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity
Min Chen, Li Huang, and Jin Wang
p.4360-4367
Nonredundant roles for Stat5a/b in directly regulating Foxp3
Zhengju Yao, Yuka Kanno, Marc Kerenyi, Geoffrey Stephens, Lydia Durant, Wendy T. Watford, Arian Laurence, Gertraud W. Robinson, Ethan M. Shevach, Richard Moriggl, Lothar Hennighausen, Changyou Wu, and John J. O'Shea
p.4368-4375
Intravenous immunoglobulins contain naturally occurring antibodies that mimic antineutrophil cytoplasmic antibodies and activate neutrophils in a TNF-dependent and Fc-receptor–independent way
Sven Jarius, Peter Eichhorn, Michael H. Albert, Stefan Wagenpfeil, Manfred Wick, Bernd H. Belohradsky, Reinhard Hohlfeld, Dieter E. Jenne, and Raymond Voltz
p.4376-4382
The thymic theme of acetylcholinesterase splice variants in myasthenia gravis
Adi Gilboa-Geffen, Paul P. Lacoste, Lilach Soreq, Geraldine Cizeron-Clairac, Rozen Le Panse, Frederique Truffault, Iftach Shaked, Hermona Soreq, and Sonia Berrih-Aknin
p.4383-4391
NEOPLASIA:
The p21Waf1 pathway is involved in blocking leukemogenesis by the t(8;21) fusion protein AML1-ETO
Luke F. Peterson, Ming Yan, and Dong-Er Zhang
p.4392-4398
Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells
Letizia Venturini, Karin Battmer, Mirco Castoldi, Beate Schultheis, Andreas Hochhaus, Martina U. Muckenthaler, Arnold Ganser, Matthias Eder, and Michaela Scherr
p.4399-4405
Growth factor independent 1B (Gfi1b) is an E2A target gene that modulates Gata3 in T-cell lymphomas
Xu Wei and Barbara L. Kee
p.4406-4414
Statins synergistically potentiate 7-hydroxystaurosporine (UCN-01) lethality in human leukemia and myeloma cells by disrupting Ras farnesylation and activation
Yun Dai, Payal Khanna, Shuang Chen, Xin-Yan Pei, Paul Dent, and Steven Grant
p.4415-4423
Reversible anergy of sIgM-mediated signaling in the two subsets of CLL defined by VH-gene mutational status
C. Ian Mockridge, Kathleen N. Potter, Isla Wheatley, Louise A. Neville, Graham Packham, and Freda K. Stevenson
p.4424-4431
Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia
Francesco Fazi, Giuseppe Zardo, Vania Gelmetti, Lorena Travaglini, Alberto Ciolfi, Luciano Di Croce, Alessandro Rosa, Irene Bozzoni, Francesco Grignani, Francesco Lo-Coco, Pier Giuseppe Pelicci, and Clara Nervi
p.4432-4440
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
Patricia Pérez-Galán, Gaël Roué, Neus Villamor, Elias Campo, and Dolors Colomer
p.4441-4449
Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity
Ronan Quere, Aurelie Baudet, Bruno Cassinat, Gerald Bertrand, Jacques Marti, Laurent Manchon, David Piquemal, Christine Chomienne, and Therese Commes
p.4450-4460
The role of PKC and PDK1 in monocyte lineage specification by Ras
Lorna Pearn, Janet Fisher, Alan K. Burnett, and Richard L. Darley
p.4461-4469
The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells
Simona Colla, Fenghuang Zhan, Wei Xiong, Xiaosong Wu, Hongwei Xu, Owen Stephens, Shmuel Yaccoby, Joshua Epstein, Bart Barlogie, and John D. Shaughnessy, Jr
p.4470-4477
PHAGOCYTES:
Neutrophil elastase depends on serglycin proteoglycan for localization in granules
Carsten U. Niemann, Magnus Åbrink, Gunnar Pejler, Rikke L. Fischer, Erik I. Christensen, Stefan D. Knight, and Niels Borregaard
p.4478-4486
NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils
Sibylle von Vietinghoff, Gisela Tunnemann, Claudia Eulenberg, Maren Wellner, M. Cristina Cardoso, Friedrich C. Luft, and Ralph Kettritz
p.4487-4493
RED CELLS:
BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors
John M. Perry, Omid F. Harandi, and Robert F. Paulson
p.4494-4502
Defective targeting of hemojuvelin to plasma membrane is a common pathogenetic mechanism in juvenile hemochromatosis
Laura Silvestri, Alessia Pagani, Claudia Fazi, Gianmario Gerardi, Sonia Levi, Paolo Arosio, and Clara Camaschella
p.4503-4510
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe
Maja Vujic Spasic, Judit Kiss, Thomas Herrmann, Regina Kessler, Jens Stolte, Bruno Galy, Birgit Rathkolb, Eckhard Wolf, Wolfgang Stremmel, Matthias W. Hentze, and Martina U. Muckenthaler
p.4511-4517
STEM CELLS IN HEMATOLOGY:
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability
Charlie Mantel, Ying Guo, Man Ryul Lee, Min-Kyoung Kim, Myung-Kwan Han, Hirohiko Shibayama, Seiji Fukuda, Mervin C. Yoder, Louis M. Pelus, Kye-Seong Kim, and Hal E. Broxmeyer
p.4518-4527
TRANSFUSION MEDICINE:
Mapping helper T-cell epitopes on platelet membrane glycoprotein IIIa in chronic autoimmune thrombocytopenic purpura
Hosea Sukati, Henry G. Watson, Stanislaw J. Urbaniak, and Robert N. Barker
p.4528-4538
TRANSPLANTATION:
Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants
M. Louise Markert, Blythe H. Devlin, Marilyn J. Alexieff, Jie Li, Elizabeth A. McCarthy, Stephanie E. Gupton, Ivan K. Chinn, Laura P. Hale, Thomas B. Kepler, Min He, Marcella Sarzotti, Michael A. Skinner, Henry E. Rice, and Jeffrey C. Hoehner
p.4539-4547
Chronic GvHD decreases antiviral immune responses in allogeneic BMT
Mohammad S. Hossain, John D. Roback, Brian P. Pollack, David L. Jaye, Amelia Langston, and Edmund K. Waller
p.4548-4556
A randomized, placebo-controlled trial of oral beclomethasone dipropionate as a prednisone-sparing therapy for gastrointestinal graft-versus-host disease
David M. Hockenbery, Scott Cruickshank, Timothy C. Rodell, Ted Gooley, Friedrich Schuening, Scott Rowley, Donald David, Mark Brunvand, Brian Berryman, Sunil Abhyankar, Michelle Bouvier, and George B. McDonald, for the orBec GVHD Study Group
p.4557-4563
Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse
Nadira Durakovic, Vedran Radojcic, Mario Skarica, Karl B. Bezak, Jonathan D. Powell, Ephraim J. Fuchs, and Leo Luznik
p.4564-4574
Long-term T-cell reconstitution after hematopoietic stem-cell transplantation in primary T-cell–immunodeficient patients is associated with myeloid chimerism and possibly the primary disease phenotype
Marina Cavazzana-Calvo, Frédérique Carlier, Françoise Le Deist, Estelle Morillon, Pierre Taupin, David Gautier, Isabelle Radford-Weiss, Sophie Caillat-Zucman, Bénédicte Neven, Stephane Blanche, Rémi Cheynier, Alain Fischer, and Salima Hacein-Bey-Abina
p.4575-4581
Brief report  Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens
Richard E. Champlin, Waleska S. Perez, Jakob R. Passweg, John P. Klein, Bruce M. Camitta, Eliane Gluckman, Christopher N. Bredeson, Mary Eapen, and Mary M. Horowitz
p.4582-4585
Brief report  Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantation
Philippe Armand, Haesook T. Kim, Corey S. Cutler, Vincent T. Ho, John Koreth, Edwin P. Alyea, Robert J. Soiffer, and Joseph H. Antin
p.4586-4588
CORRESPONDENCE:
Granulocyte colony-stimulating factor and severe aplastic anemia
Blanche P. Alter and Philip S. Rosenberg
p.4589
Response: G-CSF and aplastic anemia
Gerard Socie on behalf of the Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation
p.4589-4590