INSIDE BLOOD:
KGF boosts thymic archiTECture
Yu-Waye Chu and Frances T. Hakim
p.3613-3614
Control LPS or get killed
Noam Stern-Ginossar and Ofer Mandelboim
p.3614-3615
Fc Rs join in the cascade
Francis W. Luscinskas and Tanya Mayadas
p.3615-3616
Understand tolerogenic dendritic cells
Katharina E. Tschoep and Elfriede Noessner
p.3616
ProTECtion from posttransplantation immune deficiency?
Kenneth I. Weinberg
p.3617-3618
Glis: novel modulators of TCR signaling?
Ursula Bommhardt
p.3618-3619
Survival signaling in HoxA9/Meis1 AML
Gang G. Wang and Mark P. Kamps
p.3619-3620
Braking neutrophils with PTEN
Lee-Ann H. Allen
p.3620-3621
Gene expression levels in lymphoma
Philip S. Rosenberg
p.3621
Bcl-B and Nur77/TR3: a deadly combination
Dharminder Chauhan and Kenneth C. Anderson
p.3622
BLOOD WORK:
Chronic lymphocytic leukemia: bone marrow aspirate
p.3623
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues
Silvia Parolini, Amerigo Santoro, Emanuela Marcenaro, Walter Luini, Luisa Massardi, Fabio Facchetti, David Communi, Marc Parmentier, Alessandra Majorana, Marina Sironi, Giovanna Tabellini, Alessandro Moretta, and Silvano Sozzani
p.3625-3632
Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization
Julie Catusse, Chris M. Parry, David R. Dewin, and Ursula A. Gompels
p.3633-3639
Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice
Susumu Nakae, Hajime Suto, Gerald J. Berry, and Stephen J. Galli
p.3640-3648
Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients
Cédric Lécureuil, Béhazine Combadière, Elodie Mazoyer, Olivia Bonduelle, Assia Samri, Brigitte Autran, Patrice Debré, and Christophe Combadière
p.3649-3657
CLINICAL TRIALS AND OBSERVATIONS:
Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?
Jan J. Cornelissen, Wim L. J. van Putten, Leo F. Verdonck, Matthias Theobald, Emanuel Jacky, Simon M. G. Daenen, Marinus van Marwijk Kooy, Pierre Wijermans, Harry Schouten, Peter C. Huijgens, Hans van der Lelie, Martin Fey, Augustin Ferrant, Johan Maertens, Alois Gratwohl, and Bob Lowenberg
p.3658-3666
Progression to end-stage liver disease in patients with inherited bleeding disorders and hepatitis C: an international, multicenter cohort study
Dirk Posthouwer, Michael Makris, Thynn T. Yee, Kathelijn Fischer, Joost J. van Veen, Anja Griffioen, Karel J. van Erpecum, and Eveline P. Mauser-Bunschoten
p.3667-3671
Brief report Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial
Tadeusz Robak, Krzysztof Jamroziak, Joanna Gora-Tybor, Jerzy Z. Blonski, Marek Kasznicki, Jadwiga Dwilewicz-Trojaczek, Elzbieta Wiater, Andrzej Zdunczyk, Jacek Dybowicz, Anna Dmoszynska, Maria Wojtaszko, Barbara Zdziarska, Malgorzata Calbecka, Aleksandra Kostyra, Andrzej Hellmann, Krzysztof Lewandowski, Beata Stella-Holowiecka, Kazimierz Sulek, Krzysztof Gawronski, Aleksander B. Skotnicki, Wieslaw Nowak, Krystyna Zawilska, Lucyna Molendowicz-Portala, Janusz Kloczko, Jaroslaw Sokolowski, Krzysztof Warzocha, Ilona Seferynska, Bernardeta Ceglarek, and Lech Konopka, for the Polish Adult Leukemia Group
p.3672-3675
Brief report Imatinib plus steroids induces complete remissions and prolonged survival in elderly Philadelphia chromosome-positive patients with acute lymphoblastic leukemia without additional chemotherapy: results of the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) LAL0201-B protocol
Marco Vignetti, Paola Fazi, Giuseppe Cimino, Giovanni Martinelli, Francesco Di Raimondo, Felicetto Ferrara, Giovanna Meloni, Achille Ambrosetti, Giovanni Quarta, Livio Pagano, Giovanna Rege-Cambrin, Loredana Elia, Raffaello Bertieri, Luciana Annino, Robin Foà, Michele Baccarani, and Franco Mandelli
p.3676-3678
HEMATOPOIESIS:
Involvement of Fyn kinase in Kit and integrin-mediated Rac activation, cytoskeletal reorganization, and chemotaxis of mast cells
Lionel A. Samayawardhena, Reuben Kapur, and Andrew W. B. Craig
p.3679-3686
HOXA10 is a critical regulator for hematopoietic stem cells and erythroid/megakaryocyte development
Mattias Magnusson, Ann C. M. Brun, Noriko Miyake, Jonas Larsson, Mats Ehinger, Jon Mar Bjornsson, Anton Wutz, Mikael Sigvardsson, and Stefan Karlsson
p.3687-3696
Ectopic expression of PAX5 promotes maintenance of biphenotypic myeloid progenitors coexpressing myeloid and B-cell lineage-associated genes
Kristina Anderson, Corinne Rusterholz, Robert Månsson, Christina T. Jensen, Karl Bacos, Sasan Zandi, Yutaka Sasaki, Claus Nerlov, Mikael Sigvardsson, and Sten Eirik W. Jacobsen
p.3697-3705
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells
Jiang Zhu, Russell Garrett, Younghun Jung, Yi Zhang, Nacksung Kim, Jingcheng Wang, Gerard J. Joe, Elizabeth Hexner, Yongwon Choi, Russell S. Taichman, and Stephen G. Emerson
p.3706-3712
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
A sequence variation scan of the coagulation factor VIII (FVIII) structural gene and associations with plasma FVIII activity levels
Kevin R. Viel, Deepa K. Machiah, Diane M. Warren, Manana Khachidze, Alfonso Buil, Karl Fernstrom, Juan C. Souto, Juan M. Peralta, Todd Smith, John Blangero, Sandra Porter, Stephen T. Warren, Jordi Fontcuberta, Jose M. Soria, W. Dana Flanders, Laura Almasy, and Tom E. Howard
p.3713-3724
Mapping early conformational changes in IIb and ß3 during biogenesis reveals a potential mechanism for IIbß3 adopting its bent conformation
W. Beau Mitchell, Jihong Li, Marta Murcia, Nathalie Valentin, Peter J. Newman, and Barry S. Coller
p.3725-3732
Relative antithrombotic and antihemostatic effects of protein C activator versus low-molecular-weight heparin in primates
András Gruber, Ulla M. Marzec, Leslie Bush, Enrico Di Cera, José A. Fernández, Michelle A. Berny, Erik I. Tucker, Owen J. T. McCarty, John H. Griffin, and Stephen R. Hanson
p.3733-3740
Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets
Leonardo A. Moraes, Karen E. Swales, Jessica A. Wray, Amilcar Damazo, Jonathan M. Gibbins, Timothy D. Warner, and David Bishop-Bailey
p.3741-3744
Endorepellin, the C-terminal angiostatic module of perlecan, enhances collagen-platelet responses via the 2ß1-integrin receptor
Gregory Bix, Rex A. Iozzo, Ben Woodall, Michelle Burrows, Angela McQuillan, Shelly Campbell, Gregg B. Fields, and Renato V. Iozzo
p.3745-3748
IMMUNOBIOLOGY:
Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production
Jun Kunisawa, Yosuke Kurashima, Masashi Gohda, Morio Higuchi, Izumi Ishikawa, Fumi Miura, Ikuko Ogahara, and Hiroshi Kiyono
p.3749-3756
Activation of the Hedgehog signaling pathway in T-lineage cells inhibits TCR repertoire selection in the thymus and peripheral T-cell activation
Nicola J. Rowbotham, Ariadne L. Hager-Theodorides, Marek Cebecauer, Divya K. Shah, Ekati Drakopoulou, Julian Dyson, Susan V. Outram, and Tessa Crompton
p.3757-3766
Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells
Laura Chiossone, Chiara Vitale, Francesca Cottalasso, Sara Moretti, Bruno Azzarone, Lorenzo Moretta, and Maria Cristina Mingari
p.3767-3775
Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses
Shlomo Nedvetzki, Stefanie Sowinski, Robert A. Eagle, James Harris, Frédéric Vély, Daniela Pende, John Trowsdale, Eric Vivier, Siamon Gordon, and Daniel M. Davis
p.3776-3785
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
Timothy J. Wilson, Rachel M. Presti, Ilaria Tassi, Edgar T. Overton, Marina Cella, and Marco Colonna
p.3786-3793
An essential role for IL-17 in preventing pathogen-initiated bone destruction: recruitment of neutrophils to inflamed bone requires IL-17 receptor-dependent signals
Jeffrey J. Yu, Matthew J. Ruddy, Grace C. Wong, Cornelia Sfintescu, Pamela J. Baker, Jeffrey B. Smith, Richard T. Evans, and Sarah L. Gaffen
p.3794-3802
Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells
Simona W. Rossi, Lukas T. Jeker, Tomoo Ueno, Sachiyo Kuse, Marcel P. Keller, Saulius Zuklys, Andrei V. Gudkov, Yousuke Takahama, Werner Krenger, Bruce R. Blazar, and Georg A. Holländer
p.3803-3811
Inhibitory effect of tumor cell-derived lactic acid on human T cells
Karin Fischer, Petra Hoffmann, Simon Voelkl, Norbert Meidenbauer, Julia Ammer, Matthias Edinger, Eva Gottfried, Sabine Schwarz, Gregor Rothe, Sabine Hoves, Kathrin Renner, Birgit Timischl, Andreas Mackensen, Leoni Kunz-Schughart, Reinhard Andreesen, Stefan W. Krause, and Marina Kreutz
p.3812-3819
A newly established murine immature dendritic cell line can be differentiated into a mature state, but exerts tolerogenic function upon maturation in the presence of glucocorticoid
Matthias Bros, Frank Jährling, Andrea Renzing, Nadine Wiechmann, Ngoc-Anh Dang, Arne Sutter, Ralf Ross, Jürgen Knop, Stephan Sudowe, and Angelika B. Reske-Kunz
p.3820-3829
Effective graft depletion of MiHAg T-cell specificities and consequences for graft-versus-host disease
Moniek A. de Witte, Mireille Toebes, Ji-Ying Song, Monika C. Wolkers, and Ton N. M. Schumacher
p.3830-3838
B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo
Yan Li, Gianluca Toraldo, Aimin Li, Xiaoying Yang, Hongying Zhang, Wei-Ping Qian, and M. Neale Weitzmann
p.3839-3848
Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma
Frederic Luciano, Maryla Krajewska, Paulina Ortiz-Rubio, Stan Krajewski, Dayong Zhai, Benjamin Faustin, Jean-Marie Bruey, Beatrice Bailly-Maitre, Alan Lichtenstein, Siva Kumar Kolluri, Arnold C. Satterthwait, Xiao-Kun Zhang, and John C. Reed
p.3849-3855
Stimulation of P2 receptors causes release of IL-1ß-loaded microvesicles from human dendritic cells
Cinzia Pizzirani, Davide Ferrari, Paola Chiozzi, Elena Adinolfi, Dorianna Sandonà, Erika Savaglio, and Francesco Di Virgilio
p.3856-3864
Vitamin A potentiates CpG-mediated memory B-cell proliferation and differentiation: involvement of early activation of p38MAPK
Aase Ertesvag, Hans-Christian Aasheim, Soheil Naderi, and Heidi Kiil Blomhoff
p.3865-3872
Differential effects of IL-21 and IL-15 on perforin expression, lysosomal degranulation, and proliferation in CD8 T cells of patients with human immunodeficiency virus-1 (HIV)
Lesley White, Subramaniam Krishnan, Natasa Strbo, Huanliang Liu, Michael A. Kolber, Mathias G. Lichtenheld, Rajendra N. Pahwa, and Savita Pahwa
p.3873-3880
Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between Fc RIIa and CXCR1/2
Oliver J. Florey, Michael Johns, Olubukola O. Esho, Justin C. Mason, and Dorian O. Haskard
p.3881-3889
TLR ligands differentially affect uptake and presentation of cellular antigens
Markus Michael Weck, Frank Grünebach, Daniela Werth, Christian Sinzger, Anita Bringmann, and Peter Brossart
p.3890-3894
NEOPLASIA:
The C/EBP tumor suppressor is silenced by hypermethylation in acute myeloid leukemia
Shuchi Agrawal, Wolf-Karsten Hofmann, Nicola Tidow, Mathias Ehrich, Dirk van den Boom, Steffen Koschmieder, Wolfgang E. Berdel, Hubert Serve, and Carsten Müller-Tidow
p.3895-3905
Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage
Jennifer A. Cain, Zhifu Xiang, Julie O'Neal, Friederike Kreisel, AnnaLynn Colson, Hui Luo, Lothar Hennighausen, and Michael H. Tomasson
p.3906-3914
Targeting aurora kinases as therapy in multiple myeloma
Yijiang Shi, Tony Reiman, Weiqun Li, Christopher A. Maxwell, Subrata Sen, Linda Pilarski, Tracy R. Daniels, Manuel L. Penichet, Rick Feldman, and Alan Lichtenstein
p.3915-3921
Clinical quantitation of diagnostic and predictive gene expression levels in follicular and diffuse large B-cell lymphoma by RT-PCR gene expression profiling
Ebrahim Sakhinia, Caroline Glennie, Judith A. Hoyland, Lia P. Menasce, Gerard Brady, Crispin Miller, John A. Radford, and Richard J. Byers
p.3922-3928
Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells
Wim J. E. Tissing, Monique L. den Boer, Jules P. P. Meijerink, Renee X. Menezes, Sigrid Swagemakers, Peter J. van der Spek, Stephen E. Sallan, Scott A. Armstrong, and Rob Pieters
p.3929-3935
Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials
Nataliya Kuptsova, Kenneth J. Kopecky, John Godwin, Jeanne Anderson, Ashraful Hoque, Cheryl L. Willman, Marilyn L. Slovak, and Christine B. Ambrosone
p.3936-3944.
K-RasG12D expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells
Margaret E. M. Van Meter, Ernesto Díaz-Flores, Joehleen A. Archard, Emmanuelle Passegué, Jonathan M. Irish, Nikesh Kotecha, Garry P. Nolan, Kevin Shannon, and Benjamin S. Braun
p.3945-3952
Integrated molecular profiling of SOD2 expression in multiple myeloma
Elaine M. Hurt, Suneetha B. Thomas, Benjamin Peng, and William L. Farrar
p.3953-3962
A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy
Anita Boyapati, Ming Yan, Luke F. Peterson, Joseph R. Biggs, Michelle M. Le Beau, and Dong-Er Zhang
p.3963-3971
Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia
Nuno R. dos Santos, David S. Rickman, Aurélien de Reynies, Françoise Cormier, Maryvonne Williame, Camille Blanchard, Marc-Henri Stern, and Jacques Ghysdael
p.3972-3981
NF- B-independent down-regulation of XIAP by bortezomib sensitizes HL B cells against cytotoxic drugs
Hamid Kashkar, Anke Deggerich, Jens-Michael Seeger, Benjamin Yazdanpanah, Katja Wiegmann, Dirk Haubert, Carola Pongratz, and Martin Krönke
p.3982-3988
Temporal genetic program following B-cell receptor cross-linking: altered balance between proliferation and death in healthy and malignant B cells
Laurent D. Vallat, Yuhyun Park, Cheng Li, and John G. Gribben
p.3989-3997
Trib1 and Evi1 cooperate with Hoxa and Meis1 in myeloid leukemogenesis
Guang Jin, Yukari Yamazaki, Miki Takuwa, Tomoko Takahara, Keiko Kaneko, Takeshi Kuwata, Satoshi Miyata, and Takuro Nakamura
p.3998-4005
MEK1/2 inhibitors sensitize Bcr/Abl+ human leukemia cells to the dual Abl/Src inhibitor BMS-354/825
Tri K. Nguyen, Mohamed Rahmani, Hisashi Harada, Paul Dent, and Steven Grant
p.4006-4015
Brief report Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells
Heather G. Jørgensen, Elaine K. Allan, Niove E. Jordanides, Joanne C. Mountford, and Tessa L. Holyoake
p.4016-4019
Brief report Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation
Ester Morgado, Stéphanie Albouhair, and Catherine Lavau
p.4020-4022
Brief report Concurrent transcriptional deregulation of AML1/RUNX1 and GATA factors by the AML1-TRPS1 chimeric gene in t(8;21)(q24;q22) acute myeloid leukemia
Norio Asou, Masatoshi Yanagida, Liqun Huang, Masayuki Yamamoto, Katsuya Shigesada, Hiroaki Mitsuya, Yoshiaki Ito, and Motomi Osato
p.4023-4027
PHAGOCYTES:
Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions
Kulandayan K. Subramanian, Yonghui Jia, Daocheng Zhu, Benjamin T. Simms, Hakryul Jo, Hidenori Hattori, Jian You, Joseph P. Mizgerd, and Hongbo R. Luo
p.4028-4037
RED CELLS:
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
Cindy N. Roy, Howard H. Mak, Imo Akpan, Grigoriy Losyev, David Zurakowski, and Nancy C. Andrews
p.4038-4044
Iron chelation regulates cyclin D1 expression via the proteasome: a link to iron deficiency-mediated growth suppression
Effie Nurtjahja-Tjendraputra, Dong Fu, Juanita M. Phang, and Des R. Richardson
p.4045-4054
STEM CELLS IN HEMATOLOGY:
MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines
Christian Ries, Virginia Egea, Marisa Karow, Helmut Kolb, Marianne Jochum, and Peter Neth
p.4055-4063
TRANSPLANTATION:
HLA mismatching within or outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation
Judith A. Wade, Carolyn Katovich Hurley, Steven K. Takemoto, John Thompson, Stella M. Davies, Thomas C. Fuller, Glenn Rodey, Dennis L. Confer, Harriet Noreen, Michael Haagenson, Fangyu Kan, John Klein, Mary Eapen, Stephen Spellman, and Craig Kollman
p.4064-4070
New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses
Dong Zhang, Wei Yang, Nicolas Degauque, Yan Tian, Allison Mikita, and Xin Xiao Zheng
p.4071-4079
Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation
Mathias M. Hauri-Hohl, Marcel P. Keller, Jason Gill, Katrin Hafen, Esther Pachlatko, Thomas Boulay, Annick Peter, Georg A. Holländer, and Werner Krenger
p.4080-4088
Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene
Cornelis A. M. van Bergen, Michel G. D. Kester, Inge Jedema, Mirjam H. M. Heemskerk, Simone A. P. van Luxemburg-Heijs, Freke M. Kloosterboer, W. A. Erik Marijt, Arnoud H. de Ru, M. Ron Schaafsma, Roel Willemze, Peter A. van Veelen, and J. H. Frederik Falkenburg
p.4089-4096
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease
Yanhui Xu, Andrew S. Flies, Dallas B. Flies, Gefeng Zhu, Sudarshan Anand, Sarah J. Flies, Haiying Xu, Robert A. Anders, Wayne W. Hancock, Lieping Chen, and Koji Tamada
p.4097-4104
CORRESPONDENCE:
The interaction between leukocytosis and other risk factors for thrombosis in essential thrombocythemia
Ayalew Tefferi, Naseema Gangat, and Alexandra Wolanskyj
p.4105
Why make a diagnosis?
Richard Lipton
p.4106
Response: Diagnosing VWD type 1: when is it useful and when illogical?
J. Evan Sadler
p.4106
Myelofibrosis evolving during imatinib treatment of a chronic myeloproliferative disease with coexisting BCR-ABL translocation and JAK2V617F mutation
Kais Hussein, Oliver Bock, Anna Seegers, Michael Flasshove, Felicitas Henneke, Guntram Buesche, and Hans Heinrich Kreipe
p.4106-4107
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