INSIDE BLOOD:
MCP-1 muscles in on pericytes
Simon Karpatkin
p.849-850
Diamond-Blackfan anemia: "novel" mechanisms-ribosomes and the erythron
Jeffrey M. Lipton
p.850-851
B-ware of allosensitized graft rejection
Daniel H. Fowler
p.851-852
Pairing SOCS with CD33
Edward D. Ball
p.852
Glucocorticoids in innate immunity: more transactivation than transrepression!
Mauro Perretti
p.852-853
CCR5 and HIV: the less, the better
Mario Roederer and Joseph Mattapallil
p.854
Complexity at the junction
Patrick G. Gallagher
p.854-855
RXR: no longer a stepchild
Kathleen A. Hoag and Denise E. Lackey
p.855-856
Another brick in building the thymus
Carlo Riccardi
p.856
What unleashes aberrant gene regulation in acute promyelocytic leukemia?
Jonathan D. Licht
p.857
BLOOD WORK:
Sickle cell disease with abdominal pain
p.858
PERSPECTIVES:
When is a mouse basophil not a basophil?
James J. Lee and Michael P. McGarry
p.859-861
REVIEW ARTICLES:
PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase
Rebecca J. Chan and Gen-Sheng Feng
p.862-867
REVIEWS IN TRANSLATIONAL HEMATOLOGY:
New agents that stimulate erythropoiesis
H. Franklin Bunn
p.868-873
Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features
Brunangelo Falini, Ildo Nicoletti, Massimo F. Martelli, and Cristina Mecucci
p.874-885
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity
Uta E. Höpken, Antje M. Wengner, Christoph Loddenkemper, Harald Stein, Markus M. Heimesaat, Armin Rehm, and Martin Lipp
p.886-895
CLINICAL TRIALS AND OBSERVATIONS:
Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia
Albert Moghrabi, Donna E. Levy, Barbara Asselin, Ronald Barr, Luis Clavell, Craig Hurwitz, Yvan Samson, Marshall Schorin, Virginia K. Dalton, Steven E. Lipshultz, Donna S. Neuberg, Richard D. Gelber, Harvey J. Cohen, Stephen E. Sallan, and Lewis B. Silverman
p.896-904
Risk-adapted BEACOPP regimen can reduce the cumulative dose of chemotherapy for standard and high-risk Hodgkin lymphoma with no impairment of outcome
Eldad J. Dann, Rachel Bar-Shalom, Ada Tamir, Nissim Haim, Menachem Ben-Shachar, Irit Avivi, Tzila Zuckerman, Mark Kirschbaum, Odelia Goor, Diana Libster, Jacob M. Rowe, and Ron Epelbaum
p.905-909
Molecular relapse in adult standard-risk ALL patients detected by prospective MRD monitoring during and after maintenance treatment: data from the GMALL 06/99 and 07/03 trials
Thorsten Raff, Nicola Gökbuget, Silke Lüschen, Regina Reutzel, Matthias Ritgen, Sebastian Irmer, Sebastian Böttcher, Heinz-August Horst, Michael Kneba, Dieter Hoelzer, and Monika Brüggemann, for the GMALL Study Group
p.910-915
Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia
David Ng, Ousmane Toure, Ming-Hui Wei, Diane C. Arthur, Fatima Abbasi, Laura Fontaine, Gerald E. Marti, Joseph F. Fraumeni, Jr, Lynn R. Goldin, Neil Caporaso, and Jorge R. Toro
p.916-925
Risk- and response-based classification of childhood B-precursor acute lymphoblastic leukemia: a combined analysis of prognostic markers from the Pediatric Oncology Group (POG) and Children's Cancer Group (CCG)
Kirk R. Schultz, D. Jeanette Pullen, Harland N. Sather, Jonathan J. Shuster, Meenakshi Devidas, Michael J. Borowitz, Andrew J. Carroll, Nyla A. Heerema, Jeffrey E. Rubnitz, Mignon L. Loh, Elizabeth A. Raetz, Naomi J. Winick, Stephen P. Hunger, William L. Carroll, Paul S. Gaynon, and Bruce M. Camitta
p.926-935
Prophylactic human granulocyte colony-stimulating factor after induction therapy in pediatric acute myeloid leukemia
Thomas Lehrnbecher, Martin Zimmermann, Dirk Reinhardt, Michael Dworzak, Jan Stary, and Ursula Creutzig
p.936-943
Outcome of 609 adults after relapse of acute lymphoblastic leukemia (ALL); an MRC UKALL12/ECOG 2993 study
Adele K. Fielding, Susan M. Richards, Rajesh Chopra, Hillard M. Lazarus, Mark R. Litzow, Georgina Buck, I. Jill Durrant, Selina M. Luger, David I. Marks, Ian M. Franklin, Andrew K. McMillan, Martin S. Tallman, Jacob M. Rowe, and Anthony H. Goldstone, Medical Research Council of the United Kingdom Adult ALL Working Party and the Eastern Cooperative Oncology Group
p.944-950
Brief report Humoral immune response and immunoglobulin G Fc receptor genotype are associated with better clinical outcome following idiotype vaccination in follicular lymphoma patients regardless of their response to induction chemotherapy
Wen-Kai Weng, Debra Czerwinski, and Ronald Levy
p.951-953
HEMATOPOIESIS:
PDGFR -expressing mesenchyme regulates thymus growth and the availability of intrathymic niches
William E. Jenkinson, Simona W. Rossi, Sonia M. Parnell, Eric J. Jenkinson, and Graham Anderson
p.954-960
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
MCP-1 mediates TGF-ß-induced angiogenesis by stimulating vascular smooth muscle cell migration
Jing Ma, Qiang Wang, Teng Fei, Jing-Dong Jackie Han, and Ye-Guang Chen
p.987-994
Eosinophils are a major intravascular location for tissue factor storage and exposure
Christine Moosbauer, Eberhard Morgenstern, Susan L. Cuvelier, Davit Manukyan, Kiril Bidzhekov, Sybille Albrecht, Peter Lohse, Kamala D. Patel, and Bernd Engelmann
p.995-1002
Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice
Xunzhen Zheng, Weihong Li, Jian-Ming Gu, Dongfeng Qu, Gary L. Ferrell, Naomi L. Esmon, and Charles T. Esmon
p.1003-1009
VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
Satoshi Hirakawa, Lawrence F. Brown, Shohta Kodama, Karri Paavonen, Kari Alitalo, and Michael Detmar
p.1010-1017
ADAP is required for normal IIbß3 activation by VWF/GP Ib-IX-V and other agonists
Ana Kasirer-Friede, Barry Moran, Jennifer Nagrampa-Orje, Ken Swanson, Zaverio M. Ruggeri, Burkhart Schraven, Benjamin G. Neel, Gary Koretzky, and Sanford J. Shattil
p.1018-1025
A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation
Susan Sather, Karla D. Kenyon, Jerry B. Lefkowitz, Xiayuan Liang, Brian C. Varnum, Peter M. Henson, and Douglas K. Graham
p.1026-1033
IMMUNOBIOLOGY:
IL-7-induced proliferation of recent thymic emigrants requires activation of the PI3K pathway
Louise Swainson, Sandrina Kinet, Cedric Mongellaz, Marion Sourisseau, Telmo Henriques, and Naomi Taylor
p.1034-1042
Human plasmacytoid dendritic cells regulate immune responses to Epstein-Barr virus (EBV) infection and delay EBV-related mortality in humanized NOD-SCID mice
Wai Hon Lim, Svjetlana Kireta, Graeme Randolph Russ, and Patrick Toby Hewlett Coates
p.1043-1050
Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling
Jean-Claude Twizere, Jean-Yves Springael, Mathieu Boxus, Arsène Burny, Franck Dequiedt, Jean-François Dewulf, Julie Duchateau, Daniel Portetelle, Patrice Urbain, Carine Van Lint, Patrick L. Green, Renaud Mahieux, Marc Parmentier, Luc Willems, and Richard Kettmann
p.1051-1060
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
Selinda J. Orr, Nuala M. Morgan, Joanne Elliott, James F. Burrows, Christopher J. Scott, Daniel W. McVicar, and James A. Johnston
p.1061-1068
Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts
Ivona Pandrea, Cristian Apetrei, Shari Gordon, Joseph Barbercheck, Jason Dufour, Rudolf Bohm, Beth Sumpter, Pierre Roques, Preston A. Marx, Vanessa M. Hirsch, Amitinder Kaur, Andrew A. Lackner, Ronald S. Veazey, and Guido Silvestri
p.1069-1076
The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors
Shawn G. Payne, Carole A. Oskeritzian, Rachael Griffiths, Preeti Subramanian, Suzanne E. Barbour, Charles E. Chalfant, Sheldon Milstien, and Sarah Spiegel
p.1077-1085
Early acquisition of cytolytic function and transcriptional changes in a primary CD8+ T-cell response in vivo
Christopher Chiu, Adrian G. Heaps, Vincenzo Cerundolo, Andrew J. McMichael, Charles R. Bangham, and Margaret F. C. Callan
p.1086-1094
Annexin-1 modulates T-cell activation and differentiation
Fulvio D'Acquisto, Ahmed Merghani, Emilio Lecona, Guglielmo Rosignoli, Karim Raza, Christopher D. Buckley, Roderick J. Flower, and Mauro Perretti
p.1095-1102
Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation
Djordje Atanackovic, Julia Arfsten, Yanran Cao, Sacha Gnjatic, Frank Schnieders, Katrin Bartels, Georgia Schilling, Christiane Faltz, Christine Wolschke, Judith Dierlamm, Gerd Ritter, Thomas Eiermann, Dieter Kurt Hossfeld, Axel R. Zander, Achim A. Jungbluth, Lloyd J. Old, Carsten Bokemeyer, and Nicolaus Kröger
p.1103-1112
Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN- /ß on antigen cross-presentation
Randy S. Longman, Deborah Braun, Sandra Pellegrini, Charles M. Rice, Robert B. Darnell, and Matthew L. Albert
p.1113-1122
Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function
Jennifer L. Brogdon, Yongyao Xu, Susanne J. Szabo, Shaojian An, Francis Buxton, Dalia Cohen, and Qian Huang
p.1123-1130
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
Luisa Cervantes-Barragan, Roland Züst, Friedemann Weber, Martin Spiegel, Karl S. Lang, Shizuo Akira, Volker Thiel, and Burkhard Ludewig
p.1131-1137
Distinct memory CD4+ T-cell subsets mediate immune recognition of Epstein Barr virus nuclear antigen 1 in healthy virus carriers
Kevin N. Heller, Jenica Upshaw, Beza Seyoum, Henry Zebroski, and Christian Münz
p.1138-1146
PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization
Tami L. Bach, Wesley T. Kerr, Yanfeng Wang, Eve Marie Bauman, Purnima Kine, Eileen L. Whiteman, Renell S. Morgan, Edward K. Williamson, E. Michael Ostap, Janis K. Burkhardt, Gary A. Koretzky, Morris J. Birnbaum, and Charles S. Abrams
p.1147-1155
Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor
Yumiko Wada, Rongzhen Lu, Dan Zhou, John Chu, Teresa Przewloka, Shijie Zhang, Long Li, Yaming Wu, June Qin, Vishwasenani Balasubramanyam, James Barsoum, and Mitsunori Ono
p.1156-1164
Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells
David Vremec, Meredith O'Keeffe, Hubertus Hochrein, Martina Fuchsberger, Irina Caminschi, Mireille Lahoud, and Ken Shortman
p.1165-1173
Massive infection and loss of CD4+ T cells occurs in the intestinal tract of neonatal rhesus macaques in acute SIV infection
Xiaolei Wang, Terri Rasmussen, Bapi Pahar, Bhawna Poonia, Xavier Alvarez, Andrew A. Lackner, and Ronald S. Veazey
p.1174-1181
Brief report Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1
Yumi Tone, Taizo Wada, Fumie Shibata, Tomoko Toma, Yoko Hashida, Yoshihito Kasahara, Shoichi Koizumi, and Akihiro Yachie
p.1182-1184
NEOPLASIA:
Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities
Julie A. McEarchern, Ezogelin Oflazoglu, Leigh Francisco, Charlotte F. McDonagh, Kristine A. Gordon, Ivan Stone, Kerry Klussman, Eileen Turcott, Nico van Rooijen, Paul Carter, Iqbal S. Grewal, Alan F. Wahl, and Che-Leung Law
p.1185-1192
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CßII
Simon T. Abrams, Tasneem Lakum, Ke Lin, Gemma M. Jones, Andrew T. Treweeke, Mosavar Farahani, Mair Hughes, Mirko Zuzel, and Joseph R. Slupsky
p.1193-1201
Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays
Dietmar Pfeifer, Milena Pantic, Ilona Skatulla, Justyna Rawluk, Clemens Kreutz, Uwe M. Martens, Paul Fisch, Jens Timmer, and Hendrik Veelken
p.1202-1210
Bcr-Abl signaling through the PI-3/S6 kinase pathway inhibits nuclear translocation of the transcription factor Bach2, which represses the antiapoptotic factor heme oxygenase-1
Chikashi Yoshida, Fumiko Yoshida, Daniel E. Sears, Stephen M. Hart, Dai Ikebe, Akihiko Muto, Subham Basu, Kazuhiko Igarashi, and Junia V. Melo
p.1211-1219
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)
Dharminder Chauhan, Paola Neri, Mugdha Velankar, Klaus Podar, Teru Hideshima, Mariateresa Fulciniti, Pierfrancesco Tassone, Noopur Raje, Constantine Mitsiades, Nicholas Mitsiades, Paul Richardson, Leigh Zawel, Mary Tran, Nikhil Munshi, and Kenneth C. Anderson
p.1220-1227
Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications
Natalia Gonzalez-Paz, Wee J. Chng, Rebecca F. McClure, Emily Blood, Martin M. Oken, Brian Van Ness, C. David James, Paul J. Kurtin, Kimberly Henderson, Gregory J. Ahmann, Morie Gertz, Martha Lacy, Angela Dispenzieri, Philip R. Greipp, and Rafael Fonseca
p.1228-1232
Brief report A common genetic variant in XPD associates with risk of 5q- and 7q-deleted acute myeloid leukemia
Alexandra G. Smith, Lisa J. Worrillow, and James M. Allan
p.1233-1236
Brief report Expression of a bcr-1 isoform of RAR -PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2
Matthew J. Walter, Rhonda E. Ries, Jon R. Armstrong, John S. Park, Elaine R. Mardis, and Timothy J. Ley
p.1237-1240
Brief report Long-term serial analysis of X-chromosome inactivation patterns and JAK2 V617F mutant levels in patients with essential thrombocythemia show that minor mutant-positive clones can remain stable for many years
Rosemary E. Gale, Anthony J.R. Allen, Michael J. Nash, and David C. Linch
p.1241-1243
Brief report Continuous delivery of human type I interferons ( /ß) has significant activity against acute myeloid leukemia cells in vitro and in a xenograft model
Reuben Benjamin, Asim Khwaja, Nalini Singh, Jenny McIntosh, Anthony Meager, Meenu Wadhwa, Christian Streck, Catherine Ng, Andrew M. Davidoff, and Amit C. Nathwani
p.1244-1247
PHAGOCYTES:
Dual role for RhoA in suppression and induction of cytokines in the human neutrophil
Michael B. Fessler, Patrick G. Arndt, Ingo Just, Jerry A. Nick, Kenneth C. Malcolm, and G. Scott Worthen
p.1248-1256
Rho GTPase Rac1 is critical for neutrophil migration into the lung
Marie-Dominique Filippi, Kathleen Szczur, Chad E. Harris, and Pierre-Yves Berclaz
p.1257-1264
Glucocorticoids induce differentiation of a specifically activated, anti-inflammatory subtype of human monocytes
Jan Ehrchen, Lars Steinmüller, Katarzyna Barczyk, Klaus Tenbrock, Wolfgang Nacken, Martin Eisenacher, Ursula Nordhues, Clemens Sorg, Cord Sunderkötter, and Johannes Roth
p.1265-1274
RED CELLS:
Impaired ribosome biogenesis in Diamond-Blackfan anemia
Valérie Choesmel, Daniel Bacqueville, Jacques Rouquette, Jacqueline Noaillac-Depeyre, Sébastien Fribourg, Aurore Crétien, Thierry Leblanc, Gil Tchernia, Lydie Da Costa, and Pierre-Emmanuel Gleizes
p.1275-1283
Tropomyosin modulates erythrocyte membrane stability
Xiuli An, Marcela Salomao, Xinhua Guo, Walter Gratzer, and Narla Mohandas
p.1284-1288
Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface
Alexander G. Maier, Melanie Rug, Matthew T. O'Neill, James G. Beeson, Matthias Marti, John Reeder, and Alan F. Cowman
p.1289-1297
STEM CELLS IN HEMATOLOGY:
Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment
Fernando Anjos-Afonso and Dominique Bonnet
p.1298-1306
TRANSPLANTATION:
Preformed antibody, not primed T cells, is the initial and major barrier to bone marrow engraftment in allosensitized recipients
Patricia A. Taylor, Michael J. Ehrhardt, Matthew M. Roforth, Jessica M. Swedin, Angela Panoskaltsis-Mortari, Jonathan S. Serody, and Bruce R. Blazar
p.1307-1315
Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis
Nicolaus Kröger, Anita Badbaran, Ernst Holler, Joachim Hahn, Guido Kobbe, Martin Bornhäuser, Andreas Reiter, Tatjana Zabelina, Axel R. Zander, and Boris Fehse
p.1316-1321
Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem-cell transplants from related donors in adult patients with hematologic malignancies after myeloablative conditioning regimen
Satoshi Takahashi, Jun Ooi, Akira Tomonari, Takaaki Konuma, Nobuhiro Tsukada, Maki Oiwa-Monna, Kenji Fukuno, Michihiro Uchiyama, Kashiya Takasugi, Tohru Iseki, Arinobu Tojo, Takuhiro Yamaguchi, and Shigetaka Asano
p.1322-1330
Brief report Evidence for an immune barrier after in utero hematopoietic-cell transplantation
William H. Peranteau, Masayuki Endo, Obinna O. Adibe, and Alan W. Flake
p.1331-1333
CORRESPONDENCE:
High frequency of the JAK2 V617F mutation in patients with thrombocytosis (platelet count > 600 x 109/L) and ringed sideroblasts more than 15% considered as MDS/MPD, unclassifiable
Norbert Gattermann, Johan Billiet, Ralf Kronenwett, Esther Zipperer, Ulrich Germing, Friedel Nollet, Arnold Criel, and Dominik Selleslag
p.1334-1335
Conventional Western blotting techniques will not reliably quantify p210BCR-ABL1 levels in CML mononuclear cells
Hetal Patel, Stephen B. Marley, and Myrtle Y. Gordon
p.1335
Response: Conventional Western blotting techniques will not reliably quantify p210 BCR-ABL
Mhairi Copland, Ashley Hamilton, and Tessa L. Holyoake
p.1336
Update on factor V Leiden association with venous thromboembolism in the LITE Study
Aaron R. Folsom for the LITE Investigators
p.1336-1337
Methylation and expression of the p16INK4A tumor suppressor gene in multiple myeloma
Amel Dib, Bart Barlogie, John D. Shaughnessy, Jr, and Walter Michael Kuehl
p.1337-1338
|
