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BLOOD 109 (8) – Abril 2007 (2ª quinzena)

INSIDE BLOOD:

Filgrastim therapy: a bone of contention
Elisabeth G. Blanchard and Seth J. Corey
p.3125-3126

Genomics in myeloma: the philosopher's stone?
Andreas Rosenwald
p.3126

Karyng about karyotyping in adult ALL
Frederick R. Appelbaum
p.3127

Unraveling CML phase by phase
John Goldman
p.3128

Inside-out, outside-in: what's the difference?
Edward F. Plow and Yan-Qing Ma
p.3128-3129

MEGAprofiles provide big insightsinto platelet function
Wadie F. Bahou
p.3129-3130

Serotonin: a real blast for T cells
John Gordon and Nicholas M. Barnes
p.3130-3131

The CBFB-MYH11 butterfly effect in hematopoiesis
Andre J. van Wijnen and Gary S. Stein
p.3131-3132

Multiple myeloma and FISH (but no CHIPS)
Rafael Fonseca
p.3132-3133

Spectrin unfolding mutations: kinks in the links
Luanne L. Peters
p.3133-3134

Nonmyeloablative allotransplantation for myeloma: light and shade
Michele Cavo
p.3134-3135

Win-WNT pathway in ALL
Gertjan J. L. Kaspers
p.3135-3136

Blood orchestrates a leukocyte integrin trio
Joel S. Bennett
p.3137-3138

PLENARY PAPERS:

Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor
Matilde León-Ponte,, Gerard P. Ahern, and Peta J. O'Connell
p.3139-3146

PERSPECTIVE:

Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions
Darwin J. Prockop and Scott D. Olson
p.3147-3151

REVIEW ARTICLES:

Diamond-Blackfan anemia: erythropoiesis lost in translation
Johan Flygare and Stefan Karlsson
p.3152-3154

REVIEW IN TRANSLATIONAL HEMATOLOGY:

The cytoprotective protein C pathway
Laurent O. Mosnier, Berislav V. Zlokovic, and John H. Griffin
p.3161-3172

CHEMOKINES, CYTOKINES, AND INTERLEUKINS:

Brief report Influence of ERK activation on decreased chemotaxis of mature human cord blood monocyte–derived dendritic cells to CCL19 and CXCL12
Geling Li, Sunanda Basu, Myung-Kwan Han, Young-June Kim, and Hal E. Broxmeyer
p.3173-3176

CLINICAL TRIALS AND OBSERVATIONS:

Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib
George Mulligan, Constantine Mitsiades, Barb Bryant, Fenghuang Zhan, Wee J. Chng, Steven Roels, Erik Koenig, Andrew Fergus, Yongsheng Huang, Paul Richardson, William L. Trepicchio, Annemiek Broyl, Pieter Sonneveld, John D. Shaughnessy, Jr, P. Leif Bergsagel, David Schenkein, Dixie-Lee Esseltine, Anthony Boral, and Kenneth C. Anderson
p.3177-3188

Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
Anthony V. Moorman, Christine J. Harrison, Georgina A. N. Buck, Sue M. Richards, Lorna M. Secker-Walker, Mary Martineau, Gail H. Vance, Athena M. Cherry, Rodney R. Higgins, Adele K. Fielding, Letizia Foroni, Elisabeth Paietta, Martin S. Tallman, Mark R. Litzow, Peter H. Wiernik, Jacob M. Rowe, Anthony H. Goldstone, and Gordon W. Dewald, on behalf of the Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Adult Leukaemia Working Party of the United Kingdom and the Eastern Cooperative Oncology Group
p.3189-3197

T–B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3 subunit of the T-cell antigen receptor complex
Joseph L. Roberts, Jens Peter H. Lauritsen, Myriah Cooney, Roberta E. Parrott, Elisa O. Sajaroff, Chan M. Win, Michael D. Keller, Jeffery H. Carpenter, Juan Carabana, Michael S. Krangel, Marcella Sarzotti, Xiao-Ping Zhong, David L. Wiest, and Rebecca H. Buckley
p.3198-3206

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis
Jorge Cortes, Philippe Rousselot, Dong-Wook Kim, Ellen Ritchie, Nelson Hamerschlak, Steven Coutre, Andreas Hochhaus, Francois Guilhot, Giuseppe Saglio, Jane Apperley, Oliver Ottmann, Neil Shah, Philipp Erben, Susan Branford, Prasheen Agarwal, Ashwin Gollerkeri, and Michele Baccarani
p.3207-3213

Neurologic complications associated with intrathecal liposomal cytarabine given prophylactically in combination with high-dose methotrexate and cytarabine to patients with acute lymphocytic leukemia
Elias Jabbour, Susan O'Brien, Hagop Kantarjian, Guillermo Garcia-Manero, Alessandra Ferrajoli, Farhad Ravandi, Maria Cabanillas, and Deborah A. Thomas
p.3214-3218

Distinct EBV and CMV reactivation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia
Phillip Scheinberg, Steven H. Fischer, Li Li, Olga Nunez, Colin O. Wu, Elaine M. Sloand, Jeffrey I. Cohen, Neal S. Young, and A. John Barrett
p.3219-3224

HEMATOPOIESIS:

Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach
Hana Raslova, Audrey Kauffmann, Dalila Sekkaï, Hugues Ripoche, Fréderic Larbret, Thomas Robert, Diana Tronik Le Roux, Guido Kroemer, Najet Debili, Philippe Dessen, Vladimir Lazar, and William Vainchenker
p.3225-3234

Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection
Alyssa D. Gregory, Lisa A. Hogue, Thomas W. Ferkol, and Daniel C. Link
p.3235-3243

Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis
Marc J. Heikens, Thai M. Cao, Chikako Morita, Sarah L. DeHart, and Schickwann Tsai
p.3244-3252

MafB negatively regulates RANKL-mediated osteoclast differentiation
Kabsun Kim, Jung Ha Kim, Junwon Lee, Hye Mi Jin, Hyun Kook, Kyung Keun Kim, Soo Young Lee, and Nacksung Kim
p.3253-3259

HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:

Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins
Iain C. Macaulay, Marloes R. Tijssen, Daphne C. Thijssen-Timmer, Arief Gusnanto, Michael Steward, Philippa Burns, Cordelia F. Langford, Peter D. Ellis, Frank Dudbridge, Jaap-Jan Zwaginga, Nicholas A. Watkins, C. Ellen van der Schoot, and Willem H. Ouwehand
p.3260-3269

Tissue-type plasminogen activator–mediated shedding of astrocytic low-density lipoprotein receptor–related protein increases the permeability of the neurovascular unit
Rohini Polavarapu, Maria Carolina Gongora, Hong Yi, Sripriya Ranganthan, Daniel A. Lawrence, Dudley Strickland, and Manuel Yepes
p.3270-3278

Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
Leon J. Schurgers, Kirsten J. F. Teunissen, Karly Hamulyák, Marjo H. J. Knapen, Hogne Vik, and Cees Vermeer
p.3279-3283

Structure-function analysis reveals discrete ß3 integrin inside-out and outside-in signaling pathways in platelets
Zhiying Zou, Hong Chen, Alec A. Schmaier, Richard O. Hynes, and Mark L. Kahn
p.3284-3290

Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice
Tillmann Cyrus, Yuemang Yao, Tao Ding, Jean Michel Dogné, and Domenico Praticò
p.3291-3296

Brief report X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation
Venée N. Tubman, Jason E. Levine, Dean R. Campagna, Rita Monahan-Earley, Ann M. Dvorak, Ellis J. Neufeld, and Mark D. Fleming
p.3297-3299

IMMUNOBIOLOGY:

Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin
Paul R. Hess, Carie Barnes, Matthew D. Woolard, Michael D. L. Johnson, John M. Cullen, Edward J. Collins, and Jeffrey A. Frelinger
p.3300-3307

TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation
Cheng Qian, Huazhang An, Yizhi Yu, Shuxun Liu, and Xuetao Cao
p.3308-3315

The Pten/PI3K pathway governs the homeostasis of V14iNKT cells
Hiroyuki Kishimoto, Toshiaki Ohteki, Nobuyuki Yajima, Koichi Kawahara, Miyuki Natsui, Satoru Kawarasaki, Koichi Hamada, Yasuo Horie, Yoshiaki Kubo, Seiji Arase, Masaru Taniguchi, Bart Vanhaesebroeck, Tak Wah Mak, Toru Nakano, Shigeo Koyasu, Takehiko Sasaki, and Akira Suzuki
p.3316-3324

Nonmalignant T cells stimulate growth of T-cell lymphoma cells in the presence of bacterial toxins
Anders Woetmann, Paola Lovato, Karsten W. Eriksen, Thorbjørn Krejsgaard, Tord Labuda, Qian Zhang, Anne-Merethe Mathiesen, Carsten Geisler, Arne Svejgaard, Mariusz A. Wasik, and Niels Ødum
p.3325-3332

Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell–natural killer cell crosstalk
Jun Xu, Ayan K. Chakrabarti, Jennifer L. Tan, Lisheng Ge, Andrea Gambotto, and Nikola L. Vujanovic
p.3333-3341

Notch activity synergizes with B-cell–receptor and CD40 signaling to enhance B-cell activation
Matthew Thomas, Marco Calamito, Bhaskar Srivastava, Ivan Maillard, Warren S. Pear, and David Allman
p.3342-3350

HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells
Adriano Boasso, Jean-Philippe Herbeuval, Andrew W. Hardy, Stephanie A. Anderson, Matthew J. Dolan, Dietmar Fuchs, and Gene M. Shearer
p.3351-3359

Vav proteins control MyD88-dependent oxidative burst
Ana V. Miletic, Daniel B. Graham, Vivianne Montgrain, Keiko Fujikawa, Tracie Kloeppel, Karry Brim, Brian Weaver, Robert Schreiber, Ramnik Xavier, and Wojciech Swat
p.3360-3368

Plasmacytoid DCs regulate recall responses by rapid induction of IL-10 in memory T cells
Espen O. Kvale, Yngvar Fløisand, Fridtjof Lund-Johansen, Halvor Rollag, Lorant Farkas, Smita Ghanekar, Per Brandtzaeg, Frode L. Jahnsen, and Johanna Olweus
p.3369-3376

Combined deficiencies in Bruton tyrosine kinase and phospholipase C2 arrest B-cell development at a pre-BCR+ stage
Shengli Xu, Koon-Guan Lee, Jianxin Huo, Tomohiro Kurosaki, and Kong-Peng Lam
p.3377-3384

Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells
Yael Haberman, Idit Ziv, Yaara Gorzalczany, Koret Hirschberg, Leonide Mittleman, Mitsunori Fukuda, and Ronit Sagi-Eisenberg
p.3385-3392

Cell-free production of scFv fusion proteins: an efficient approach for personalized lymphoma vaccines
Gregory Kanter, Junhao Yang, Alexei Voloshin, Shoshana Levy, James R. Swartz, and Ronald Levy
p.3393-3399

NEOPLASIA:

ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia
Deepa B. Shankar, Junling Li, Paul Tapang, J. Owen McCall, Lori J. Pease, Yujia Dai, Ru-Qi Wei, Daniel H. Albert, Jennifer J. Bouska, Donald J. Osterling, Jun Guo, Patrick A. Marcotte, Eric F. Johnson, Niru Soni, Kresna Hartandi, Michael R. Michaelides, Steven K. Davidsen, Saul J. Priceman, Jenny C. Chang, Katrin Rhodes, Neil Shah, Theodore B. Moore, Kathleen M. Sakamoto, and Keith B. Glaser
p.3400-3408

Members of the glutathione and ABC-transporter families are associated with clinical outcome in patients with diffuse large B-cell lymphoma
Charalambos Andreadis, Phyllis A. Gimotty, Peter Wahl, Rachel Hammond, Jane Houldsworth, Stephen J. Schuster, and Timothy R. Rebbeck
p.3409-3416

A novel PAX5-ELN fusion protein identified in B-cell acute lymphoblastic leukemia acts as a dominant negative on wild-type PAX5
Marina Bousquet, Cyril Broccardo, Cathy Quelen, Fabienne Meggetto, Emilienne Kuhlein, Georges Delsol, Nicole Dastugue, and Pierre Brousset
p.3417-3423

Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner
Angela C. Hirbe, Özge Uluçkan, Elizabeth A. Morgan, Mark C. Eagleton, Julie L. Prior, David Piwnica-Worms, Kathryn Trinkaus, Anthony Apicelli, and Katherine Weilbaecher
p.3424-3431

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus
Ling Zhao, Jennifer L. Cannons, Stacie Anderson, Martha Kirby, Liping Xu, Lucio H. Castilla, Pamela L. Schwartzberg, Rémy Bosselut, and P. Paul Liu
p.3432-3440

Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo
Guang-Biao Zhou, Hui Kang, Lan Wang, Li Gao, Ping Liu, Jun Xie, Feng-Xiang Zhang, Xiang-Qin Weng, Zhi-Xiang Shen, Jue Chen, Long-Jun Gu, Ming Yan, Dong-Er Zhang, Sai-Juan Chen, Zhen-Yi Wang, and Zhu Chen
p.3441-3450

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL)
Takashi Akasaka, Theodore Balasas, Lisa J. Russell, Kei-ji Sugimoto, Aneela Majid, Renata Walewska, E. Loraine Karran, David G. Brown, Kelvin Cain, Lana Harder, Stefan Gesk, Jose Ignacio Martin-Subero, Mark G. Atherton, Monika Brüggemann, María José Calasanz, Teresa Davies, Oskar A. Haas, Anne Hagemeijer, Helena Kempski, Michel Lessard, Debra M. Lillington, Sarah Moore, Florence Nguyen-Khac, Isabelle Radford-Weiss, Claudia Schoch, Stéphanie Struski, Polly Talley, Melanie J. Welham, Helen Worley, Jon C. Strefford, Christine J. Harrison, Reiner Siebert, and Martin J. S. Dyer
p.3451-3461

Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia
José Román-Gómez, Lucia Cordeu, Xabier Agirre, Antonio Jiménez-Velasco, Edurne San José-Eneriz, Leire Garate, María José Calasanz, Anabel Heiniger, Antonio Torres, and Felipe Prosper
p.3462-3469

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells
Geoffrey A. Bartholomeusz, Moshe Talpaz, Vaibhav Kapuria, Ling Yuan Kong, Shimei Wang, Zeev Estrov, Waldemar Priebe, Ji Wu, and Nicholas J. Donato
p.3470-3478

Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)
Sophia S. Wang, Susan L. Slager, Paul Brennan, Elizabeth A. Holly, Silvia De Sanjose, Leslie Bernstein, Paolo Boffetta, James R. Cerhan, Marc Maynadie, John J. Spinelli, Brian C. H. Chiu, Pier Luigi Cocco, Fiona Mensah, Yawei Zhang, Alexandra Nieters, Luigino Dal Maso, Paige M. Bracci, Adele Seniori Costantini, Paolo Vineis, Richard K. Severson, Eve Roman, Wendy Cozen, Dennis Weisenburger, Scott Davis, Silvia Franceschi, Carlo La Vecchia, Lenka Foretova, Nikolaus Becker, Anthony Staines, Martine Vornanen, Tongzhang Zheng, and Patricia Hartge
p.3479-3488

Genetic abnormalities and survival in multiple myeloma: the experience of the Intergroupe Francophone du Myélome
Hervé Avet-Loiseau, Michel Attal, Philippe Moreau, Catherine Charbonnel, Frédéric Garban, Cyrille Hulin, Serge Leyvraz, Mauricette Michallet, Ibrahim Yakoub-Agha, Laurent Garderet, Gérald Marit, Lucienne Michaux, Laurent Voillat, Marc Renaud, Bernard Grosbois, Gaelle Guillerm, Lotfi Benboubker, Mathieu Monconduit, Catherine Thieblemont, Philippe Casassus, Denis Caillot, Anne-Marie Stoppa, Jean-Jacques Sotto, Marc Wetterwald, Charles Dumontet, Jean-Gabriel Fuzibet, Isabelle Azais, Véronique Dorvaux, Marc Zandecki, Régis Bataille, Stéphane Minvielle, Jean-Luc Harousseau, Thierry Facon, and Claire Mathiot
p.3489-3495

Brief report Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
Stephane Picard, Karine Titier, Gabriel Etienne, Emmanuelle Teilhet, Dominique Ducint, Marie-Agnes Bernard, Regis Lassalle, Gerald Marit, Josy Reiffers, Bernard Begaud, Nicholas Moore, Mathieu Molimard, and Francois-Xavier Mahon
p.3496-3499

Brief report MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation
Alexander J. A. Deutsch, Ariane Aigelsreiter, Philipp B. Staber, Alfred Beham, Werner Linkesch, Christian Guelly, Ruth I. Brezinschek, Margareta Fruhwirth, Werner Emberger, Maike Buettner, Christine Beham-Schmid, and Peter Neumeister
p.3500-3504

Brief report Chemotherapy exposure increases leukemia cell stiffness
Wilbur A. Lam, Michael J. Rosenbluth, and Daniel A. Fletcher
p.3505-3508

Brief report Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
Zhihong Zeng, Dos D. Sarbassov, Ismael J. Samudio, Karen W. L. Yee, Mark F. Munsell, C. Ellen Jackson, Francis J. Giles, David M. Sabatini, Michael Andreeff, and Marina Konopleva
p.3509-3512

PHAGOCYTES:

The ß-tail domain (ßTD) regulates physiologic ligand binding to integrin CD11b/CD18
Vineet Gupta, Annette Gylling, José Luis Alonso, Takashi Sugimori, Petre Ianakiev, Jiang-Ping Xiong, and M. Amin Arnaout
p.3513-3520

Generation of activation-specific human anti-Mß2 single-chain antibodies as potential diagnostic tools and therapeutic agents
Steffen U. Eisenhardt, Meike Schwarz, Nils Schallner, Juliana Soosairajah, Nicole Bassler, Dexing Huang, Christoph Bode, and Karlheinz Peter
p.3521-3528

Natural history and early diagnosis of LAD-1/variant syndrome
Taco W. Kuijpers, Robin van Bruggen, Nanne Kamerbeek, Anton T. J. Tool, Gonul Hicsonmez, Aytemiz Gurgey, Axel Karow, Arthur J. Verhoeven, Karl Seeger, Özden Sanal, Charlotte Niemeyer, and Dirk Roos
p.3529-3537

RED CELLS:

Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding
Colin P. Johnson, Massimiliano Gaetani, Vanessa Ortiz, Nishant Bhasin, Sandy Harper, Patrick G. Gallagher, David W. Speicher, and Dennis E. Discher
p.3538-3543

Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell 4ß1integrin: role in adhesion of sickle red blood cells to endothelial cells
Wassim El Nemer, Marie-Paule Wautier, Cécile Rahuel, Pierre Gane, Patricia Hermand, Frédéric Galactéros, Jean-Luc Wautier, Jean-Pierre Cartron, Yves Colin, and Caroline Le Van Kim
p.3544-3551

RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload
Patrizia Cavadini, Giorgio Biasiotto, Maura Poli, Sonia Levi, Rosanna Verardi, Isabella Zanella, Manuela Derosas, Rosaria Ingrassia, Marcella Corrado, and Paolo Arosio
p.3552-3559

Molecular basis of glutathione reductase deficiency in human blood cells
Nanne M. Kamerbeek, Rob van Zwieten, Martin de Boer, Gert Morren, Herma Vuil, Natalja Bannink, Carsten Lincke, Koert M. Dolman, Katja Becker, R. Heiner Schirmer, Stephan Gromer, and Dirk Roos
p.3560-3566

Brief report Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis
Corinne Pondarre, Dean R. Campagna, Brendan Antiochos, Lindsay Sikorski, Howard Mulhern, and Mark D. Fleming
p.3567-3569

STEM CELLS IN HEMATOLOGY:

Chromatin-modifying agents permit human hematopoietic stem cells to undergo multiple cell divisions while retaining their repopulating potential
Hiroto Araki, Kazumi Yoshinaga, Piernicola Boccuni, Yan Zhao, Ronald Hoffman, and Nadim Mahmud
p.3570-3578

TRANSPLANTATION:

Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta1
Mari H. Dallas, Barbara Varnum-Finney, Paul J. Martin, and Irwin D. Bernstein
p.3579-3587

Reduced-intensity conditioning for myeloma: lower nonrelapse mortality but higher relapse rates compared with myeloablative conditioning
Charles Crawley, Simona Iacobelli, Bo Björkstrand, Jane F. Apperley, Dietger Niederwieser, and Gösta Gahrton, for the Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
p.3588-3594

Patients with adenosine deaminase deficiency surviving after hematopoietic stem cell transplantation are at high risk of CNS complications
Manfred Hönig, Michael H. Albert, Ansgar Schulz, Monika Sparber-Sauer, Catharina Schütz, Bernd Belohradsky, Tayfun Güngör, Markus T. Rojewski, Harald Bode, Ulrich Pannicke, Dominique Lippold, Klaus Schwarz, Klaus-Michael Debatin, Michael S. Hershfield, and Wilhelm Friedrich
p.3595-3602

Brief report Reduction of GVHD and enhanced antitumor effects after adoptive infusion of alloreactive Ly49-mismatched NK cells from MHC-matched donors
Andreas Lundqvist, J. Philip McCoy, Leigh Samsel, and Richard Childs
p.3603-3606

CORRESPONDENCE:

Vitamin K supplementation during oral anticoagulation: no real cause for concern
Elizabeth Sconce, Hilary Wynne, and Farhad Kamali
p.3607

Response: vitamin K supplementation during oral anticoagulation: no real cause for concern
Elizabeth Sconce, Hilary Wynne, and Farhad Kamali
p.3607-3608

Acute thrombocytopenia caused by sensitivity to the glucuronide conjugate of acetaminophen
Daniel W. Bougie, Ana I. Benito, Luis I. Sanchez-Abarca, Ricardo Torres, Jessica Birenbaum, and Richard H. Aster
p.3608-3609

Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs
Deborah L. White, Verity A. Saunders, Steven R. Quinn, Paul W. Manley, and Timothy P. Hughes
p.3609-3610

Survival of genetic subtypes of relapsed myeloma may be modulated by secondary events
Wee J. Chng, George Mulligan, Barbara Bryant, and Leif Bergsagel
p.3610-3611

The serum-free light chain assay cannot replace 24-hour urine protein estimation in patients with plasma cell dyscrasias
Seema Singhal, Regina Stein, Eric Vickrey, and Jayesh Mehta
p.3611-3612


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