INSIDE BLOOD:
Hemangioblasts: of mice and men
Mervin C. Yoder
p.2667-2668
CD28: beyond just T-cell costimulation
Xian C. Li and Mohamed H. Sayegh
p.2668-2669
Totally tubular: virally induced endothelial tube formation
Philip E. Pellett
p.2669-2670
Interferon limits lentiviral vectors in the liver
Roland W. Herzog
p.2670-2671
Bringing IL-2 down to earth
Jonathan D. Powell
p.2671-2672
Toward a new therapeutic backbone in myeloma
Paul Richardson
p.2672-2673
Be careful what you wish for?
Adele K. Fielding
p.2673-2674
Targeting the mast cell: beyond KIT
Cem Akin
p.2674-2675
The "NO" tipping point
Gregory M. Vercellotti
p.2675
Brave new world: birth of immunity
Robert Bortolussi
p.2675-2676
BLOOD WORK:
Histoplasmosis
p.2677
PLENARY PAPERS:
Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures
Marion Kennedy, Sunita L. D'Souza, Macarena Lynch-Kattman, Staci Schwantz, and Gordon Keller
p.2679-2687
PERSPECTIVE:
Donor cell leukemia: insight into cancer stem cells and the stem cell niche
Catherine M. Flynn and Dan S. Kaufman
p.2688-2692
REVIEW ARTICLES:
Regulation of protein synthesis by the heme-regulated eIF2 kinase: relevance to anemias
Jane-Jane Chen
p.2693-2699
REVIEW IN TRANSLATIONAL HEMATOLOGY:
Aberrant NF-B signaling in lymphoma: mechanisms, consequences, and therapeutic implications
Philipp J. Jost and Jürgen Ruland
p.2700-2707
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma
Yazan Alsayed, Hai Ngo, Judith Runnels, Xavier Leleu, Ujjal K. Singha, Costas M. Pitsillides, Joel A. Spencer, Teresa Kimlinger, Joanna M. Ghobrial, Xiaoying Jia, Ganwei Lu, Michael Timm, Ashok Kumar, Daniel Côté, Israel Veilleux, Karen E. Hedin, G. David Roodman, Thomas E. Witzig, Andrew L. Kung, Teru Hideshima, Kenneth C. Anderson, Charles P. Lin, and Irene M. Ghobrial
p.2708-2717
Human herpesvirus 8 acute infection of endothelial cells induces monocyte chemoattractant protein 1–dependent capillary-like structure formation: role of the IKK/NF-B pathway
Elisabetta Caselli, Simona Fiorentini, Carla Amici, Dario Di Luca, Arnaldo Caruso, and M. Gabriella Santoro
p.2718-2726
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-B–regulated gene products and TAK1-mediated NF-B activation
Gautam Sethi, Kwang Seok Ahn, Manoj K. Pandey, and Bharat B. Aggarwal
p.2727-2735
CLINICAL TRIALS AND OBSERVATIONS:
Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents
Mitchell S. Cairo, Mary Gerrard, Richard Sposto, Anne Auperin, C. Ross Pinkerton, Jean Michon, Claire Weston, Sherrie L. Perkins, Martine Raphael, Keith McCarthy, Catherine Patte, and on behalf of the FAB LMB96 International Study Committee
p.2736-2743
Pharmacodynamics and safety of intravenous pegaspargase during remission induction in adults aged 55 years or younger with newly diagnosed acute lymphoblastic leukemia
Dan Douer, Henry Yampolsky, Lewis J. Cohen, Kristy Watkins, Alexandra M. Levine, Antonia P. Periclou, and Vassilios I. Avramis
p.2744-2750
Hyperacute GVHD: risk factors, outcomes, and clinical implications
Rima M. Saliba, Marcos de Lima, Sergio Giralt, Borje Andersson, Issa F. Khouri, Chitra Hosing, Shubhra Ghosh, Joyce Neumann, Yvonne Hsu, Jorge De Jesus, Muzaffar H. Qazilbash, Richard E. Champlin, and Daniel R. Couriel
p.2751-2758
Intensified 12-week CHOP (I-CHOP) plus G-CSF compared with standard 24-week CHOP (CHOP-21) for patients with intermediate-risk aggressive non-Hodgkin lymphoma: a phase 3 trial of the Dutch-Belgian Hemato-Oncology Cooperative Group (HOVON)
Leo F. Verdonck, Annelise Notenboom, Daphne D. de Jong, Marius A. MacKenzie, Gregor E. G. Verhoef, Mark H. H. Kramer, Gert J. Ossenkoppele, Jeanette K. Doorduijn, Pieter Sonneveld, and Gustaaf W. van Imhoff
p.2759-2766
Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myeloma
Antonio Palumbo, Maria Teresa Ambrosini, Giulia Benevolo, Patrizia Pregno, Norbert Pescosta, Vincenzo Callea, Clotilde Cangialosi, Tommaso Caravita, Fortunato Morabito, Pellegrino Musto, Sara Bringhen, Patrizia Falco, Ilaria Avonto, Federica Cavallo, and Mario Boccadoro, for the Italian Multiple Myeloma Network, Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA)
p.2767-2772
Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients
Catherine Patte, Anne Auperin, Mary Gerrard, Jean Michon, Ross Pinkerton, Richard Sposto, Claire Weston, Martine Raphael, Sherrie L. Perkins, Keith McCarthy, and Mitchell S. Cairo, for the FAB/LMB96 International Study Committee
p.2773-2780
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias
Ivana Gojo, Anchalee Jiemjit, Jane B. Trepel, Alex Sparreboom, William D. Figg, Sandra Rollins, Michael L. Tidwell, Jacqueline Greer, Eun Joo Chung, Min-Jung Lee, Steven D. Gore, Edward A. Sausville, James Zwiebel, and Judith E. Karp
p.2781-2790
Brief report Prophylactic administration of imatinib after hematopoietic cell transplantation for high-risk Philadelphia chromosome–positive leukemia
Paul A. Carpenter, David S. Snyder, Mary E. D. Flowers, Jean E. Sanders, Theodore A. Gooley, Paul J. Martin, Frederick R. Appelbaum, and Jerald P. Radich
p.2791-2793
Brief report Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and Marrow Transplantation (EBMT)
Gerard Socie, Jean-Yves Mary, Hubert Schrezenmeier, Judith Marsh, Andrea Bacigalupo, Anna Locasciulli, Monica Fuehrer, Albert Bekassy, Andre Tichelli, and Jakob Passweg
p.2794-2796
GENE THERAPY:
In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance
Brian D. Brown, Giovanni Sitia, Andrea Annoni, Ehud Hauben, Lucia Sergi Sergi, Anna Zingale, Maria Grazia Roncarolo, Luca G. Guidotti, and Luigi Naldini
p.2797-2805
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation
Stéphanie Coupel, Anne Moreau, Mohamed Hamidou, Vaclav Horejsi, Jean-Paul Soulillou, and Béatrice Charreau
p.2806-2814
Prognostic value of anti-ADAMTS13 antibody features (Ig isotype, titer, and inhibitory effect) in a cohort of 35 adult French patients undergoing a first episode of thrombotic microangiopathy with undetectable ADAMTS13 activity
Silvia Ferrari, Friedrich Scheiflinger, Manfred Rieger, Geert Mudde, Martine Wolf, Paul Coppo, Jean-Pierre Girma, Elie Azoulay, Christian Brun-Buisson, Fadi Fakhouri, Jean-Paul Mira, Eric Oksenhendler, Pascale Poullin, Eric Rondeau, Nicolas Schleinitz, Benoit Schlemmer, Jean-Louis Teboul, Philippe Vanhille, Jean-Paul Vernant, Dominique Meyer, and Agnès Veyradier, for the French and Clinical Biological Network on Adult Thrombotic Microangiopathies
p.2815-2822
Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
Leon J. Schurgers, Henri M. H. Spronk, Berry A. M. Soute, Paul M. Schiffers, Jo G. R. DeMey, and Cees Vermeer
p.2823-2831
Adenovirus-induced thrombocytopenia: the role of von Willebrand factor and P-selectin in mediating accelerated platelet clearance
Maha Othman, Andrea Labelle, Ian Mazzetti, Hisham S. Elbatarny, and David Lillicrap
p.2832-2839
Effect of von Willebrand factor Y/C1584 on in vivo protein level and function and interaction with ABO blood group
James Anthony Davies, Peter William Collins, Lee Sarah Hathaway, and Derrick John Bowen
p.2840-2846
Gene expression profiles identify a role for cyclooxygenase 2–dependent prostanoid generation in BMP6-induced angiogenic responses
Rongqin Ren, Peter C. Charles, Chunlian Zhang, Yaxu Wu, Hong Wang, and Cam Patterson
p.2847-2853
Engulfment of apoptotic cells by microvascular endothelial cells induces proinflammatory responses
Torsten Kirsch, Alexander Woywodt, Michaela Beese, Kristin Wyss, Joon-Keun Park, Uta Erdbruegger, Barbara Hertel, Hermann Haller, and Marion Haubitz
p.2854-2862
IMMUNOBIOLOGY:
Cartography of gene expression in CD8 single cells: novel CCR7– subsets suggest differentiation independent of CD45RA expression
Marta Monteiro, César Evaristo, Agnès Legrand, Antonino Nicoletti, and Benedita Rocha
p.2863-2870
Modulation of tryptophan catabolism by human leukemic cells results in the conversion of CD25– into CD25+ T regulatory cells
Antonio Curti, Simona Pandolfi, Barbara Valzasina, Michela Aluigi, Alessandro Isidori, Elisa Ferri, Valentina Salvestrini, Giuseppina Bonanno, Sergio Rutella, Ilaria Durelli, Alberto L. Horenstein, Francesca Fiore, Massimo Massaia, Mario P. Colombo, Michele Baccarani, and Roberto M. Lemoli
p.2871-2877
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells
Sanmay Bandyopadhyay, Myrianne Duré, Monika Paroder, Noemí Soto-Nieves, Irene Puga, and Fernando Macián
p.2878-2886
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells
Ezra Aksoy, Valentina Albarani, Muriel Nguyen, Jean-Francois Laes, Jean-Louis Ruelle, Dominique De Wit, Fabienne Willems, Michel Goldman, and Stanislas Goriely
p.2887-2893
T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling
Jonathan A. Deane, Michael G. Kharas, Jean S. Oak, Linda N. Stiles, Ji Luo, Travis I. Moore, Hong Ji, Christian Rommel, Lewis C. Cantley, Thomas E. Lane, and David A. Fruman
p.2894-2902
Disease-associated mutations in CIAS1 induce cathepsin B–dependent rapid cell death of human THP-1 monocytic cells
Akihiro Fujisawa, Naotomo Kambe, Megumu Saito, Ryuta Nishikomori, Hideaki Tanizaki, Nobuo Kanazawa, Souichi Adachi, Toshio Heike, Junji Sagara, Takashi Suda, Tatsutoshi Nakahata, and Yoshiki Miyachi
p.2903-2911
Slow disease progression and robust therapy-mediated CD4+ T-cell recovery are associated with efficient thymopoiesis during HIV-1 infection
Marie-Lise Dion, Rebeka Bordi, Joumana Zeidan, Robert Asaad, Mohammed-Rachid Boulassel, Jean-Pierre Routy, Micheal M. Lederman, Rafick-Pierre Sekaly, and Remi Cheynier
p.2912-2920
Induction of Th2 type immunity in a mouse system reveals a novel immunoregulatory role of basophils
Keunhee Oh, Tao Shen, Graham Le Gros, and Booki Min
p.2921-2927
-defensins block the early steps of HIV-1 infection: interference with the binding of gp120 to CD4
Lucinda Furci, Francesca Sironi, Monica Tolazzi, Lia Vassena, and Paolo Lusso
p.2928-2936
Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin–mediated neutrophil rolling
Jovanka Bestebroer, Miriam J. J. G. Poppelier, Laurien H. Ulfman, Peter J. Lenting, Cecile V. Denis, Kok P. M. van Kessel, Jos A. G. van Strijp, and Carla J. C. de Haas
p.2936-2943
Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-ß signaling in activated T lymphocytes
Dimitrios Tzachanis, Lequn Li, Esther M. Lafuente, Alla Berezovskaya, Gordon J. Freeman, and Vassiliki A. Boussiotis
p.2944-2952
Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response
Carole Bourquin, Laura Schmidt, Veit Hornung, Cornelia Wurzenberger, David Anz, Nadja Sandholzer, Susanne Schreiber, Andreas Voelkl, Gunther Hartmann, and Stefan Endres
p.2953-2960
TACI regulates IgA production by APRIL in collaboration with HSPG
Daisuke Sakurai, Hidenori Hase, Yumiko Kanno, Hidefumi Kojima, Ko Okumura, and Tetsuji Kobata
p.2961-2967
Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28
Vincenzo Mirenda, Sarah J. Jarmin, Rachel David, Julian Dyson, Diane Scott, Yan Gu, Robert I. Lechler, Klaus Okkenhaug, and Federica M. Marelli-Berg
p.2968-2977
Brief report HIV-1 infection and pathogenesis in a novel humanized mouse model
Liguo Zhang, Grigoriy I. Kovalev, and Lishan Su
p.2978-2981
Brief report CpG oligodeoxynucleotides allow for effective adoptive T-cell therapy in chronic retroviral infection
Anke R. M. Kraft, Frank Krux, Simone Schimmer, Claes Ohlen, Philip D. Greenberg, and Ulf Dittmer
p.2982-2984
Brief report A neoepitope generated by an FLT3 internal tandem duplication (FLT3-ITD) is recognized by leukemia-reactive autologous CD8+ T cells
Claudine Graf, Florian Heidel, Stefan Tenzer, Markus P. Radsak, Fian K. Solem, Cedrik M. Britten, Christoph Huber, Thomas Fischer, and Thomas Wölfel
p.2985-2988
NEOPLASIA:
Comprehensive characterization of IGHV3-21–expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
Riccardo Bomben, Michele Dal Bo, Daniela Capello, Dania Benedetti, Daniela Marconi, Antonella Zucchetto, Francesco Forconi, Rossana Maffei, Emanuela M. Ghia, Luca Laurenti, Pietro Bulian, Maria Ilaria Del Principe, Giuseppe Palermo, Mia Thorsélius, Massimo Degan, Renato Campanini, Anna Guarini, Giovanni Del Poeta, Richard Rosenquist, Dimitar G. Efremov, Roberto Marasca, Robin Foà, Gianluca Gaidano, and Valter Gattei
p.2989-2998
Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study
Steven M. Kornblau, Deborah E. Banker, Derek Stirewalt, Danny Shen, Elizabeth Lemker, Srdan Verstovsek, Zeev Estrov, Stefan Faderl, Jorge Cortes, Miloslav Beran, C. Ellen Jackson, Wenjing Chen, Elihu Estey, and Frederick R. Appelbaum
p.2999-3006
Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation
Pauline Rimmelé, Olivier Kosmider, Patrick Mayeux, Françoise Moreau-Gachelin, and Christel Guillouf
p.3007-3014
Comprehensive analysis of homeobox genes in Hodgkin lymphoma cell lines identifies dysregulated expression of HOXB9 mediated via ERK5 signaling and BMI1
Stefan Nagel, Christof Burek, Letizia Venturini, Michaela Scherr, Hilmar Quentmeier, Corinna Meyer, Andreas Rosenwald, Hans G. Drexler, and Roderick A. F. MacLeod
p.3015-3023
HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma
Therese Standal, Niels Abildgaard, Unn-Merete Fagerli, Berit Stordal, Øyvind Hjertner, Magne Borset, and Anders Sundan
p.3024-3030
Identification of MCL1 as a novel target in neoplastic mast cells in systemic mastocytosis: inhibition of mast cell survival by MCL1 antisense oligonucleotides and synergism with PKC412
Karl J. Aichberger, Matthias Mayerhofer, Karoline V. Gleixner, Maria-Theresa Krauth, Alexander Gruze, Winfried F. Pickl, Volker Wacheck, Edgar Selzer, Leonhard Müllauer, Hermine Agis, Christian Sillaber, and Peter Valent
p.3031-3041
NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor
Wenlin Du, Yutaka Hattori, Taketo Yamada, Kunio Matsumoto, Toshikazu Nakamura, Morihiko Sagawa, Takemi Otsuki, Takako Niikura, Toshihiro Nukiwa, and Yasuo Ikeda
p.3042-3049
Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study
Unhee Lim, Sophia S. Wang, Patricia Hartge, Wendy Cozen, Linda E. Kelemen, Stephen Chanock, Scott Davis, Aaron Blair, Maryjean Schenk, Nathaniel Rothman, and Qing Lan
p.3050-3059
IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma
Juan Carlos Ramos, Phillip Ruiz, Jr, Lee Ratner, Isildinha M. Reis, Carlos Brites, Celia Pedroso, Gerald E. Byrne, Jr, Ngoc L. Toomey, Valentine Andela, Edward W. Harhaj, Izidore S. Lossos, and William J. Harrington, Jr
p.3060-3068
Overexpression of nucleolin in chronic lymphocytic leukemia cells induces stabilization of bcl2 mRNA
Yoko Otake, Sridharan Soundararajan, Tapas K. Sengupta, Ebenezer A. Kio, James C. Smith, Mauricio Pineda-Roman, Robert K. Stuart, Eleanor K. Spicer, and Daniel J. Fernandes
p.3069-3075
Brief report CD10–MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features
Kennosuke Karube, Ying Guo, Junji Suzumiya, Yasuo Sugita, Yuko Nomura, Kohei Yamamoto, Kei Shimizu, Shirou Yoshida, Hideki Komatani, Morishige Takeshita, Masahiro Kikuchi, Naoya Nakamura, Osamu Takasu, Fumiko Arakawa, Hiroyuki Tagawa, Masao Seto, and Koichi Ohshima
p.3076-3079
Brief report Connective tissue growth factor (CTGF) expression and outcome in adult patients with acute lymphoblastic leukemia
Olga Sala-Torra, Holly M. Gundacker, Derek L. Stirewalt, Paula A. Ladne, Era L. Pogosova-Agadjanyan, Marilyn L. Slovak, Cheryl L. Willman, Shelly Heimfeld, David H. Boldt, and Jerald P. Radich
p.3080-3083
PHAGOCYTES:
Brief report Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils
Lars C. Jacobsen, Kim Theilgaard-Mönch, Erik I. Christensen, and Niels Borregaard
p.3084-3087
RED CELLS
Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability
Lewis L. Hsu, Hunter C. Champion, Sally A. Campbell-Lee, Trinity J. Bivalacqua, Elizabeth A. Manci, Bhalchandra A. Diwan, Daniel M. Schimel, Audrey E. Cochard, Xunde Wang, Alan N. Schechter, Constance T. Noguchi, and Mark T. Gladwin
p.3088-3098
TRANSFUSION MEDICINE:
Mouse models of IgG- and IgM-mediated hemolysis
David A. Schirmer, Shuh-Chyung Song, Jeffrey P. Baliff, Stephanie O. Harbers, Raphael A. Clynes, Anna Krop-Watorek, Gregory R. Halverson, Marcin Czerwinski, and Steven L. Spitalnik
p.3099-3107
TRANSPLANTATION:
Extended follow-up of methotrexate-free immunosuppression using sirolimus and tacrolimus in related and unrelated donor peripheral blood stem cell transplantation
Corey Cutler, Shuli Li, Vincent T. Ho, John Koreth, Edwin Alyea, Robert J. Soiffer, and Joseph H. Antin
p.3108-3114
Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse
Benny J. Chen, Divino Deoliveira, Xiuyu Cui, Ngocdiep T. Le, Jessica Son, John F. Whitesides, and Nelson J. Chao
p.3115-3123
ERRATUM:
Erratum in Moreaux et al. CD200 is a new prognostic factor in multiple myeloma
p.2717
Erratum in Joiner et al. Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes.
p.2735
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