INSIDE BLOOD:
Memory T cells: death by acquisition
Ralph A. Reisfeld
p.2269-2270
The granulocyte connection in MPD-associated thrombosis
Ayalew Tefferi
p.2270-2271
Closing the gap in CML
Jacob M. Rowe
p.2271
Endothelial cell–based therapy for hematopoiesis
Dan G. Duda
p.2272-2273
Bruton tyrosine kinase (Btk): key for signaling via Toll-like receptor 8
Ofer Levy
p.2273-2274
EDITORIALS:
A digital exam for hematologists
Sanford J. Shattil
p.2275
PLENARY PAPERS:
A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
John D. Shaughnessy, Jr, Fenghuang Zhan, Bart E. Burington, Yongsheng Huang, Simona Colla, Ichiro Hanamura, James P. Stewart, Bob Kordsmeier, Christopher Randolph, David R. Williams, Yan Xiao, Hongwei Xu, Joshua Epstein, Elias Anaissie, Somashekar G. Krishna, Michele Cottler-Fox, Klaus Hollmig, Abid Mohiuddin, Mauricio Pineda-Roman, Guido Tricot, Frits van Rhee, Jeffrey Sawyer, Yazan Alsayed, Ronald Walker, Maurizio Zangari, John Crowley, and Bart Barlogie
p.2276-2284
REVIEW ARTICLES:
Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions
Anetta Undas, Kathleen E. Brummel-Ziedins, and Kenneth G. Mann
p.2285-2292
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-B–regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
Anjana Bhardwaj, Gautam Sethi, Saroj Vadhan-Raj,, Carlos Bueso-Ramos, Yasunari Takada, Upasna Gaur, Asha S. Nair, Shishir Shishodia, and Bharat B. Aggarwal
p.2293-2302
CLINICAL TRIALS AND OBSERVATIONS:
Dasatinib induces notable hematologic and cytogenetic responses in chronic-phase chronic myeloid leukemia after failure of imatinib therapy
Andreas Hochhaus, Hagop M. Kantarjian, Michele Baccarani, Jeffrey H. Lipton, Jane F. Apperley, Brian J. Druker, Thierry Facon, Stuart L. Goldberg, Francisco Cervantes, Dietger Niederwieser, Richard T. Silver, Richard M. Stone, Timothy P. Hughes, Martin C. Muller, Rana Ezzeddine, Athena M. Countouriotis, and Neil P. Shah
p.2303-2309
Leukocytosis is a risk factor for thrombosis in essential thrombocythemia: interaction with treatment, standard risk factors, and Jak2 mutation status
Alessandra Carobbio, Guido Finazzi, Vittoria Guerini, Orietta Spinelli, Federica Delaini, Roberto Marchioli, Giovanna Borrelli, Alessandro Rambaldi, and Tiziano Barbui
p.2310-2313
Minimally differentiated acute myeloid leukemia (FAB AML-M0) is associated with an adverse outcome in children: a report from the Children's Oncology Group, studies CCG-2891 and CCG-2961
Draga Barbaric, Todd A. Alonzo, Robert B. Gerbing, Soheil Meshinchi, Nyla A. Heerema, Dorothy R. Barnard, Beverly J. Lange, William G. Woods, Robert J. Arceci, and Franklin O. Smith
p.2314-2321
Brief report Pneumococcal conjugate vaccine provides early protective antibody responses in children after related and unrelated allogeneic hematopoietic stem cell transplantation
Roland Meisel, Lisa Kuypers, Uta Dirksen, Ralf Schubert, Bernd Gruhn, Gabriele Strauss, Karin Beutel, Andreas H. Groll, Ulrich Duffner, Renate Blütters-Sawatzki, Wolfgang Holter, Tobias Feuchtinger, Hans-Peter Grüttner, Horst Schroten, Stefan Zielen, Christian Ohmann, Hans-Jürgen Laws, and Dagmar Dilloo, for the Impfung von Kindern nach allogener Stammzelltransplantation (IKAST) Study Group
p.2322-2326
Brief report Prognosis of children with acute lymphoblastic leukemia (ALL) and intrachromosomal amplification of chromosome 21 (iAMP21)
Anthony V. Moorman, Susan M. Richards, Hazel M. Robinson, Jon C. Strefford, Brenda E. S. Gibson, Sally E. Kinsey, Tim O. B. Eden, Ajay J. Vora, Christopher D. Mitchell, and Christine J. Harrison, on behalf of the UK Medical Research Council (MRC)/National Cancer Research Institute (NCRI) Childhood Leukaemia Working Party (CLWP)
p.2327-2330
GENE THERAPY:
Facilitating matched pairing and expression of TCR chains introduced into human T cells
Jürgen Kuball, Michelle L. Dossett, Matthias Wolfl, William Y. Ho, Ralf-Holger Voss, Carla Fowler, and Philip D. Greenberg
p.2331-2338
HEMATOPOIESIS:
Naive recirculating B cells mature simultaneously in the spleen and bone marrow
Annaiah Cariappa, Catharine Chase, Haoyuan Liu, Paul Russell, and Shiv Pillai
p.2339-2345
RhoH is important for positive thymocyte selection and T-cell receptor signaling
Tatjana Dorn, Ursula Kuhn, Gerd Bungartz, Sebastian Stiller, Martina Bauer, Joachim Ellwart, Thorsten Peters, Karin Scharffetter-Kochanek, Monika Semmrich, Melanie Laschinger, Bernhard Holzmann, Wolfgang E. F. Klinkert, Per Thor Straten, Tania Køllgaard, Michael Sixt, and Cord Brakebusch
p.2346-2355
Gfi1b:green fluorescent protein knock-in mice reveal a dynamic expression pattern of Gfi1b during hematopoiesis that is largely complementary to Gfi1
Lothar Vassen, Taro Okayama, and Tarik Möröy
p.2356-2364
Transplantation of vascular endothelial cells mediates the hematopoietic recovery and survival of lethally irradiated mice
John P. Chute, Garrett G. Muramoto, Alice B. Salter, Sarah K. Meadows, Dennis W. Rickman, Benny Chen, Heather A. Himburg, and Nelson J. Chao
p.2365-2372
Cytokine and integrin stimulation synergize to promote higher levels of GATA-2, c-myb, and CD34 protein in primary human hematopoietic progenitors from bone marrow
Mo A. Dao and Jan A. Nolta
p.2373-2379
Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis
Brendan J. Jenkins, Andrew W. Roberts, Claire J. Greenhill, Meri Najdovska, Therese Lundgren-May, Lorraine Robb, Dianne Grail, and Matthias Ernst
p.2380-2388
The transcription factors Scl and Lmo2 act together during development of the hemangioblast in zebrafish
Lucy J. Patterson, Martin Gering, Craig E. Eckfeldt, Anthony R. Green, Catherine M. Verfaillie, Stephen C. Ekker, and Roger Patient
p.2389-2398
CD34 cells from patients with trisomy 8 myelodysplastic syndrome (MDS) express early apoptotic markers but avoid programmed cell death by up-regulation of antiapoptotic proteins
Elaine M. Sloand, Loretta Pfannes, Gubin Chen, Simant Shah, Elena E. Solomou, John Barrett, and Neal S. Young
p.2399-2405
4-Integrin+ endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells
Gen Shinoda, Katsutsugu Umeda, Toshio Heike, Masato Arai, Akira Niwa, Feng Ma, Hirofumi Suemori, Hong Yuan Luo, David H. K. Chui, Ryuzo Torii, Masabumi Shibuya, Norio Nakatsuji, and Tatsutoshi Nakahata
p.2406-2415
Brief report Defective apoptosis of peripheral-blood lymphocytes in hyper-IgD and periodic fever syndrome
Evelien J. Bodar, Jeroen C.H. van der Hilst, Waander van Heerde, Jos W. M. van der Meer, Joost P. H. Drenth, and Anna Simon
p.2416-2418
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin
Elizabeth Sconce, Peter Avery, Hilary Wynne, and Farhad Kamali
p.2419-2423
von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins
Anil K. Chauhan, Janka Kisucka, Colin B. Lamb, Wolfgang Bergmeier, and Denisa D. Wagner
p.2424-2429
Variations in glycosylation of von Willebrand factor with O-linked sialylated T antigen are associated with its plasma levels
Carina J. M. van Schooten, Cécile V. Denis, Ton Lisman, Jeroen C. J. Eikenboom, Frank W. Leebeek, Jenny Goudemand, Edith Fressinaud, H. Marijke van den Berg, Philip G. de Groot, and Peter J. Lenting
p.2430-2437
Involvement of the fractalkine pathway in the pathogenesis of childhood hemolytic uremic syndrome
María Victoria Ramos, Gabriela C. Fernández, Natasha Patey, Pablo Schierloh, Ramón Exeni, Irene Grimoldi, Graciela Vallejo, Christian Elías-Costa, Maria del Carmen Sasiain, Howard Trachtman, Christophe Combadière, François Proulx, and Marina S. Palermo
p.2438-2445
Leukocytosis as a major thrombotic risk factor in patients with polycythemia vera
Raffaele Landolfi, Leonardo Di Gennaro, Tiziano Barbui, Valerio De Stefano, Guido Finazzi, RosaMaria Marfisi, Gianni Tognoni, and Roberto Marchioli, for the European Collaboration on Low-Dose Aspirin in Polycythemia Vera (ECLAP)
p.2446-2452
MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program
Dorothee Viemann, Katarzyna Barczyk, Thomas Vogl, Ute Fischer, Cord Sunderkötter, Klaus Schulze-Osthoff, and Johannes Roth
p.2453-2460
Src family kinases mediate neutrophil adhesion to adherent platelets
Virgilio Evangelista, Zehra Pamuklar, Antonio Piccoli, Stefano Manarini, Giuseppe Dell'Elba, Romina Pecce, Nicola Martelli, Lorenzo Federico, Mauricio Rojas, Giorgio Berton, Clifford A. Lowell, Licia Totani, and Susan S. Smyth
p.2461-2469
Comparison of the effects of antibody-coated liposomes, IVIG, and anti-RBC immunotherapy in a murine model of passive chronic immune thrombocytopenia
Rong Deng and Joseph P. Balthasar
p.2470-2476
Brief report A coding VKORC1 Asp36Tyr polymorphism predisposes to warfarin resistance
Ronen Loebstein, Ilana Dvoskin, Hillel Halkin, Manuela Vecsler, Aharon Lubetsky, Gideon Rechavi, Ninette Amariglio, Yoram Cohen, Gie Ken-Dror, Shlomo Almog, and Eva Gak
p.2477-2480
IMMUNOBIOLOGY:
Hlx homeobox transcription factor negatively regulates interferon- production in monokine-activated natural killer cells
Brian Becknell, Tiffany L. Hughes, Aharon G. Freud, Bradley W. Blaser, Jianhua Yu, Rossana Trotta, Hsiaoyin C. Mao, Marie L. Caligiuri de Jesús, Mohamad Alghothani, Don M. Benson, Jr, Amy Lehman, David Jarjoura, Danilo Perrotti, Michael D. Bates, and Michael A. Caligiuri
p.2481-2487
Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis
Sven Mostböck, Marta Catalfamo, Yutaka Tagaya, Jeffrey Schlom, and Helen Sabzevari
p.2488-2495
In the absence of IGF-1 signaling, IFN- suppresses human malignant T-cell growth
Laura Conti, Gabriella Regis, Angela Longo, Paola Bernabei, Roberto Chiarle, Mirella Giovarelli, and Francesco Novelli
p.2496-2504
Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells
Constantinos Petrovas, Yvonne M. Mueller, Ioannis D. Dimitriou, Susan R. Altork, Anupam Banerjee, Peter Sklar, Karam C. Mounzer, John D. Altman, and Peter D. Katsikis
p.2505-2513
Specific antibodies to moesin, a membrane-cytoskeleton linker protein, are frequently detected in patients with acquired aplastic anemia
Hiroyuki Takamatsu, Xingmin Feng, Tatsuya Chuhjo, Xuzhang Lu, Chiharu Sugimori, Katsuya Okawa, Miyuki Yamamoto, Shoichi Iseki, and Shinji Nakao
p.2514-2520
Generation of peripheral B cells occurs via two spatially and temporally distinct pathways
Robert Coleman Lindsley, Matthew Thomas, Bhaskar Srivastava, and David Allman
p.2521-2528
Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging
Dullei Min, Angela Panoskaltsis-Mortari, Makoto Kuro-o, Georg A. Holländer, Bruce R. Blazar, and Kenneth I. Weinberg
p.2529-2537
Vaccine-delivered HIV envelope inhibits CD4+ T-cell activation, a mechanism for poor HIV vaccine responses
Kathy Fernando, Haitao Hu, Houping Ni, James A. Hoxie, and Drew Weissman
p.2538-2544
A novel human B cell subpopulation representing the initial germinal center population to express AID
Grant R. Kolar, Darshna Mehta, Rosana Pelayo, and J. Donald Capra
p.2545-2552
Brief report Impaired Toll-like receptor 8–mediated IL-6 and TNF- production in antigen-presenting cells from patients with X-linked agammaglobulinemia
Klára Sochorová, Rudolf Horváth, Daniela Rozková, Jirí Litzman, Jirina Bartunková, Anna Sedivá, and Radek Spísek
p.2553-2556
NEOPLASIA:
The growth factor fusion construct containing B-lymphocyte stimulator (BLyS) and the toxin rGel induces apoptosis specifically in BAFF-R–positive CLL cells
Ramadevi Nimmanapalli, Mi-Ae Lyu, Min Du, Michael J. Keating, Michael G. Rosenblum, and Varsha Gandhi
p.2557-2564
Hypoxia-inducible transcription factor–1 alpha determines sensitivity of endothelial cells to the proteosome inhibitor bortezomib
Lorenzo Veschini, Daniela Belloni, Chiara Foglieni, Maria Giulia Cangi, Marina Ferrarini, Federico Caligaris-Cappio, and Elisabetta Ferrero
p.2565-2570
A phase 1/2 trial of arginine butyrate and ganciclovir in patients with Epstein-Barr virus–associated lymphoid malignancies
Susan P. Perrine, Olivier Hermine, Trudy Small, Felipe Suarez, Richard O'Reilly, Farid Boulad, Joyce Fingeroth, Melissa Askin, Arthur Levy, Steven J. Mentzer, Massimo Di Nicola, Alessandro M. Gianni, Christoph Klein, Steven Horwitz, and Douglas V. Faller
p.2571-2578
Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress
Crescent R. Isham, Jennifer D. Tibodeau, Wendy Jin, Ruifang Xu, Michael M. Timm, and Keith C. Bible
p.2579-2588
Flt3 Y591 duplication and Bcl-2 overexpression are detected in acute myeloid leukemia cells with high levels of phosphorylated wild-type p53
Jonathan M. Irish, Nina Ånensen, Randi Hovland, Jørn Skavland, Anne-Lise Børresen-Dale, Øystein Bruserud, Garry P. Nolan, and Bjørn T. Gjertsen
p.2589-2596
Bmi-1 is induced by the Epstein-Barr virus oncogene LMP1 and regulates the expression of viral target genes in Hodgkin lymphoma cells
Amanda Dutton, Ciaran B. Woodman, Marilyn B. Chukwuma, James I. K. Last, Wenbin Wei, Martina Vockerodt, Karl R. N. Baumforth, Joanne R. Flavell, Martin Rowe, A. Malcolm R. Taylor, Lawrence S. Young, and Paul G. Murray
p.2597-2603
Brief report Activity and safety of bortezomib in multiple myeloma patients with advanced renal failure: a multicenter retrospective study
Asher A. Chanan-Khan, Jonathan L. Kaufman, Jayesh Mehta, Paul G. Richardson, Kena C. Miller, Sagar Lonial, Nikhil C. Munshi, Robert Schlossman, Joseph Tariman, and Seema Singhal
p.2604-2606
Brief report RNAi-mediated silencing of TEL/AML1 reveals a heat-shock protein– and survivin-dependent mechanism for survival
Christofer Diakos, Gerd Krapf, Christopher Gerner, Andrea Inthal, Christof Lemberger, Jozef Ban, Alexander M. Dohnal, and E. Renate Panzer-Gruemayer
p.2607-2610
RED CELLS:
Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte
Felicia M. Low, Mark B. Hampton, Alexander V. Peskin, and Christine C. Winterbourn
p.2611-2617
Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria
John D. Phillips, David P. Steensma, Michael A. Pulsipher, Gerald J. Spangrude, and James P. Kushner
p.2618-2621
The effect of deoxygenation on whole-cell conductance of red blood cells from healthy individuals and patients with sickle cell disease
Joseph A. Browning, Henry M. Staines, Hannah C. Robinson, Trevor Powell, J. Clive Ellory, and John S. Gibson
p.2622-2629
Brief report Distinct roles of Mdm2 and Mdm4 in red cell production
Marion Maetens, Gilles Doumont, Sarah De Clercq, Sarah Francoz, Pascal Froment, Eric Bellefroid, Ursula Klingmuller, Guillermina Lozano, and Jean-Christophe Marine
p.2630-2633
STEM CELLS IN HEMATOLOGY:
In vitro and in vivo arterial differentiation of human multipotent adult progenitor cells
Xabier L. Aranguren, Aernout Luttun, Carlos Clavel, Cristina Moreno, Gloria Abizanda, Miguel A. Barajas, Beatriz Pelacho, Maialen Uriz, Miriam Araña, Ana Echavarri, Mario Soriano, Enrique J. Andreu, Juana Merino, Jose Manuel Garcia-Verdugo, Catherine M. Verfaillie, and Felipe Prósper
p.2634-2642.
TRANSPLANTATION:
Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used
Yvonne Loh, Yu Oyama, Laisvyde Statkute, Kathleen Quigley, Kimberly Yaung, Elizabeth Gonda, Walter Barr, Borko Jovanovic, Robert Craig, Dusan Stefoski, Bruce Cohen, and Richard K. Burt
p.2643-2548
In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation
Vu H. Nguyen, Robert Zeiser, Daniel L. daSilva, Daisy S. Chang, Andreas Beilhack, Christopher H. Contag, and Robert S. Negrin
p.2649-2656
A phase 2/3 multicenter randomized clinical trial of ABX-CBL versus ATG as secondary therapy for steroid-resistant acute graft-versus-host disease
Margaret L. MacMillan, Daniel Couriel, Daniel J. Weisdorf, Gisela Schwab, Nancy Havrilla, Thomas R. Fleming, Saling Huang, Lorin Roskos, Shimon Slavin, Richard K. Shadduck, John DiPersio, Mary Territo, Steve Pavletic, Charles Linker, Helen E. Heslop, H. Joachim Deeg, and Bruce R. Blazar
p.2657-2662
Brief report Donor-derived cells and human graft-versus-host disease of the skin
Hideyuki Murata, Anne Janin, Christophe Leboeuf, Jean Soulier, Eliane Gluckman, Veronique Meignin, and Gerard Socie
p.2663-2665
CORRESPONDENCE:
Stubby elliptocytes are an invariable feature of leukoerythroblastosis
Michael Quigley, Ronald L. Linfesty, Kelly Bethel, and Robert Sharpe
p.2666
ERRATUM:
Erratum in Winter et al. Prognostic significance of Bcl-6 protein expression in DLBCL treated with CHOP or R-CHOP: a prospective correlative study
p.2292
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