INSIDE BLOOD:
Novel function of RANKL: eNOS activator
Dai Fukumura and Rakesh K. Jain
p.1339-1340
On the origins of megakaryocytes
John D. Crispino
p.1340-1341
Happy to have the megakaryocyte blues
Andrew D. Leavitt
p.1341
"Doing the locomotion" with the multistep paradigm
Richard M. Ransohoff, Shumei Man, and Eroboghene E. Ubogu
p.1342-1343
Endothelial cells in line
Lena Claesson-Welsh
p.1343-1344
Scientific detectives solve ashen mutant problem
Timothy A. Lyerla
p.1344
PLENARY PAPERS:
Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation
Gefei Zeng, Sarah M. Taylor, Janet R. McColm, Nicholas C. Kappas, Joseph B. Kearney, Lucy H. Williams, Mary E. Hartnett, and Victoria L. Bautch
p.1345-1352
PERSPECTIVE:
Bloodlines: the importance of mentoring for the future of hematology
Kenneth Kaushansky and Sanford J. Shattil
p.1353-1354
REVIEW IN TRANSLATIONAL HEMATOLOGY:
Beyond HLA: the significance of genomic variation for allogeneic hematopoietic stem cell transplantation
Ann Mullally and Jerome Ritz
p.1355-1362
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc
Takayuki Nakayama, Noriko Mutsuga, and Giovanna Tosato
p.1363-1372
Histone deacetylase inhibitors suppress IFN-induced up-regulation of promyelocytic leukemia protein
Jana Vlasáková, Zora Nováková, Lenka Rossmeislová, Michal Kahle, Pavel Hozák, and Zdenek Hodny
p.1373-1380
Shear flow–dependent integration of apical and subendothelial chemokines in T-cell transmigration: implications for locomotion and the multistep paradigm
Taylor H. Schreiber, Vera Shinder, Derek W. Cain, Ronen Alon, and Robert Sackstein
p.1381-1386
CLINICAL TRIALS AND OBSERVATIONS:
A phase 2 study of the farnesyltransferase inhibitor tipifarnib in poor-risk and elderly patients with previously untreated acute myelogenous leukemia
Jeffrey E. Lancet, Ivana Gojo, Jason Gotlib, Eric J. Feldman, Jacqueline Greer, Jane L. Liesveld, Laura M. Bruzek, Lawrence Morris, Youn Park, Alex A. Adjei, Scott H. Kaufmann, Elizabeth Garrett-Mayer, Peter L. Greenberg, John J. Wright, and Judith E. Karp
p.1387-1394
Prospective feasibility analysis of reduced-intensity conditioning (RIC) regimens for hematopoietic stem cell transplantation (HSCT) in elderly patients with acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS)
Elihu Estey, Marcos de Lima, Raoul Tibes, Sherry Pierce, Hagop Kantarjian, Richard Champlin, and Sergio Giralt
p.1395-1400
Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience
Maria Gabriella Mazzucconi, Paola Fazi, Sayla Bernasconi, Giulio De Rossi, Giuseppe Leone, Luigi Gugliotta, Nicola Vianelli, Giuseppe Avvisati, Francesco Rodeghiero, Angela Amendola, Carlo Baronci, Cecilia Carbone, Stefano Quattrin, Giuseppe Fioritoni, Giulio D'Alfonso, and Franco Mandelli, for the Gruppo Italiano Malattie EMatologiche dell'Adulto (GIMEMA) Thrombocytopenia Working Party
p.1401-1407
Imatinib combined with induction or consolidation chemotherapy in patients with de novo Philadelphia chromosome–positive acute lymphoblastic leukemia: results of the GRAAPH-2003 study
Adrienne de Labarthe, Philippe Rousselot, Françoise Huguet-Rigal, Eric Delabesse, Francis Witz, Sébastien Maury, Delphine Réa, Jean-Michel Cayuela, Marie-Christine Vekemans, Oumedaly Reman, Agnès Buzyn, Arnaud Pigneux, Martine Escoffre, Yves Chalandon, Elizabeth MacIntyre, Véronique Lhéritier, Jean-Paul Vernant, Xavier Thomas, Norbert Ifrah, and Hervé Dombret, for the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL)
p.1408-1413
GENE THERAPY:
Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates
Amit C. Nathwani, John T. Gray, Jenny McIntosh, Catherine Y. C. Ng, Junfang Zhou, Yunyu Spence, Melanie Cochrane, Elaine Gray, Edward G. D. Tuddenham, and Andrew M. Davidoff
p.1414-1421
HEMATOPOIESIS:
Toll-like receptors and their ligands control mesenchymal stem cell functions
Meirav Pevsner-Fischer, Vered Morad, Michal Cohen-Sfady, Liat Rousso-Noori, Alexandra Zanin-Zhorov, Shmuel Cohen, Irun R. Cohen, and Dov Zipori
p.1422-1432
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis
Joanna Tober, Anne Koniski, Kathleen E. McGrath, Radhika Vemishetti, Rachael Emerson, Karen K. L. de Mesy-Bentley, Richard Waugh, and James Palis
p.1433-1441
Caspase-8 prevents sustained activation of NF-B in monocytes undergoing macrophagic differentiation
Cédric Rébé, Séverine Cathelin, Sophie Launay, Rodolphe Filomenko, Laurent Prévotat, Coralie L'Ollivier, Emmanuel Gyan, Olivier Micheau, Steven Grant, Anne Dubart-Kupperschmitt, Michaëla Fontenay, and Eric Solary
p.1442-1450
Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2
Zhao Chen, Michael Hu, and Ramesh A. Shivdasani
p.1451-1459
The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor
Barbara Ghinassi, Massimo Sanchez, Fabrizio Martelli, Giovanni Amabile, Alessandro Maria Vannucchi, Giovanni Migliaccio, Stuart H. Orkin, and Anna Rita Migliaccio
p.1460-1471.
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
The histone methyltransferase MLL is an upstream regulator of endothelial-cell sprout formation
Florian Diehl, Lothar Rössig, Andreas M. Zeiher, Stefanie Dimmeler, and Carmen Urbich
p.1472-1478
Dissecting the role of endothelial SURVIVIN Ex3 in angiogenesis
Hugo Caldas, Jason R. Fangusaro, Daniel R. Boué, Michael P. Holloway, and Rachel A. Altura
p.1479-1489
Correlation between antiphospholipid antibodies that recognize domain I of ß2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5
Bas de Laat, Xiao-Xuan Wu, Menno van Lummel, Ronald H. W. M. Derksen, Philip G. de Groot, and Jacob H. Rand
p.1490-1494
Receptor activator of nuclear factor (NF)–B ligand (RANKL) increases vascular permeability: impaired permeability and angiogenesis in eNOS-deficient mice
Jeong-Ki Min, Young-Lai Cho, Jae-Hoon Choi, Yonghak Kim, Jeong Hun Kim, Young Suk Yu, Jaerang Rho, Naoki Mochizuki, Young-Myeong Kim, Goo Taeg Oh, and Young-Guen Kwon
p.1495-1502
Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo
Ralph Tiedt, Tibor Schomber, Hui Hao-Shen, and Radek C. Skoda
p.1503-1506
The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies
Nathalie Satta, Sylvie Dunoyer-Geindre, Guido Reber, Richard J. Fish, Francoise Boehlen, Egbert K. O. Kruithof, and Philippe de Moerloose
p.1507-1514
Caveolin-1 regulates expression of junction-associated proteins in brain microvascular endothelial cells
Li Song, Shujun Ge, and Joel S. Pachter
p.1515-1523
Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro
Yoshito Takeda, Alexander R. Kazarov, Catherine E. Butterfield, Benjamin D. Hopkins, Laura E. Benjamin, Arja Kaipainen, and Martin E. Hemler
p.1524-1532
The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules
Sreenivasulu Chintala, Jian Tan, Rashi Gautam, Michael E. Rusiniak, Xiaoli Guo, Wei Li, William A. Gahl, Marjan Huizing, Richard A. Spritz, Saunie Hutton, Edward K. Novak, and Richard T. Swank
p.1533-1540
Antiadhesive effect of fibrinogen: a safeguard for thrombus stability
Valeryi K. Lishko, Timothy Burke, and Tatiana Ugarova
p.1541-1549
IMMUNOBIOLOGY:
Kaposi sarcoma herpesvirus–encoded vFLIP and vIRF1 regulate antigen presentation in lymphatic endothelial cells
Dimitrios Lagos, Matthew W. B. Trotter, Richard J. Vart, Hsei-Wei Wang, Nick C. Matthews, Amy Hansen, Ornella Flore, Frances Gotch, and Chris Boshoff
p.1550-1558
Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification
Alicia D. Volkheimer, J. Brice Weinberg, Bethany E. Beasley, John F. Whitesides, Jon P. Gockerman, Joseph O. Moore, Garnett Kelsoe, Barbara K. Goodman, and Marc C. Levesque
p.1559-1567
L-arginine availability regulates T-lymphocyte cell-cycle progression
Paulo C. Rodriguez, David G. Quiceno, and Augusto C. Ochoa
p.1568-1573
Contribution of Toll-like receptors to the innate immune response to Gram-negative and Gram-positive bacteria
Greg Elson, Irène Dunn-Siegrist, Bruno Daubeuf, and Jérome Pugin
p.1574-1583
GSK-3 mediates differentiation and activation of proinflammatory dendritic cells
Elena Rodionova, Michael Conzelmann, Eugene Maraskovsky, Michael Hess, Michael Kirsch, Thomas Giese, Anthony D. Ho, Margot Zöller, Peter Dreger, and Thomas Luft
p.1584-1592
Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia
Rosemarijn Renckens, Joris J. T. H. Roelofs, Peter I. Bonta, Sandrine Florquin, Carlie J. M. de Vries, Marcel Levi, Peter Carmeliet, Cornelis van't Veer, and Tom van der Poll
p.1593-1601
Function of CD4+CD3– cells in relation to B- and T-zone stroma in spleen
Mi-Yeon Kim, Fiona M. McConnell, Fabrina M. C. Gaspal, Andrea White, Stephanie H. Glanville, Vasilios Bekiaris, Lucy S. K. Walker, Jorge Caamano, Eric Jenkinson, Graham Anderson, and Peter J. L. Lane
p.1602-1610
CpG DNA activation and plasma-cell differentiation of CD27– naive human B cells
Jennifer Huggins, Tina Pellegrin, Raymond E. Felgar, Chungwen Wei, Miguel Brown, Bo Zheng, Eric C. B. Milner, Steven H. Bernstein, Ignacio Sanz, and Martin S. Zand
p.1611-1619
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages
Ivan Dzhagalov, Ashley St. John, and You-Wen He
p.1620-1626
The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling
Alberto Bosque, Juan Ignacio Aguiló, M. Angeles Alava, Estela Paz-Artal, Javier Naval, Luis M. Allende, and Alberto Anel
p.1627-1635
NEOPLASIA:
The oncoprotein LMO2 is expressed in normal germinal-center B cells and in human B-cell lymphomas
Yasodha Natkunam, Shuchun Zhao, David Y. Mason, Jun Chen, Behnaz Taidi, Margaret Jones, Anne S. Hammer, Stephen Hamilton Dutoit, Izidore S. Lossos, and Ronald Levy
p.1636-1642
Prolonged exposure to FLT3 inhibitors leads to resistance via activation of parallel signaling pathways
Obdulio Piloto, Melissa Wright, Patrick Brown, Kyu-Tae Kim, Mark Levis, and Donald Small
p.1643-1652
Emodin and DHA potently increase arsenic trioxide interferon-–induced cell death of HTLV-I–transformed cells by generation of reactive oxygen species and inhibition of Akt and AP-1
Megan Brown, Marcia Bellon, and Christophe Nicot
p.1653-1659
Differential Noxa/Mcl-1 balance in peripheral versus lymph node chronic lymphocytic leukemia cells correlates with survival capacity
Laura A. Smit, Delfine Y.H. Hallaert, René Spijker, Bart de Goeij, Annelieke Jaspers, Arnon P. Kater, Marinus H.J. van Oers, Carel J.M. van Noesel, and Eric Eldering
p.1660-1668
Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl)
Klaus Podar, Marc S. Raab, Jing Zhang, Douglas McMillin, Iris Breitkreutz, Yu-Tzu Tai, Boris K. Lin, Nikhil Munshi, Teru Hideshima, Dharminder Chauhan, and Kenneth C. Anderson
p.1669-1677
Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias
Noria Harir, Christian Pecquet, Marc Kerenyi, Karoline Sonneck, Boris Kovacic, Remy Nyga, Marie Brevet, Isabelle Dhennin, Valerie Gouilleux-Gruart, Hartmut Beug, Peter Valent, Kaiss Lassoued, Richard Moriggl, and Fabrice Gouilleux
p.1678-1686
ß common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice
Andrew Kim, Kelly Morgan, Diane E. Hasz, Stephen M. Wiesner, Jennifer O. Lauchle, Jennifer L. Geurts, Miechaleen D. Diers, Doan T. Le, Scott C. Kogan, Luis F. Parada, Kevin Shannon, and David A. Largaespada
p.1687-1691
Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis
Fenghuang Zhan, Bart Barlogie, Varant Arzoumanian, Yongsheng Huang, David R. Williams, Klaus Hollmig, Mauricio Pineda-Roman, Guido Tricot, Frits van Rhee, Maurizio Zangari, Madhav Dhodapkar, and John D. Shaughnessy, Jr
p.1692-1700
Hypusination of eukaryotic initiation factor 5A (eIF5A): a novel therapeutic target in BCR-ABL–positive leukemias identified by a proteomics approach
Stefan Balabanov, Artur Gontarewicz, Patrick Ziegler, Ulrike Hartmann, Winfried Kammer, Mhairi Copland, Ute Brassat, Martin Priemer, Ilona Hauber, Thomas Wilhelm, Gerold Schwarz, Lothar Kanz, Carsten Bokemeyer, Joachim Hauber, Tessa L. Holyoake, Alfred Nordheim, and Tim H. Brümmendorf
p.1701-1711
PKC412 demonstrates JNK-dependent activity against human multiple myeloma cells
Janelle Sharkey, Tiffany Khong, and Andrew Spencer
p.1712-1719
Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities
Remco Dijkman, Remco van Doorn, Károly Szuhai, Rein Willemze, Maarten H. Vermeer, and Cornelis P. Tensen
p.1720-1727
RED CELLS:
Urea stimulation of KCl cotransport induces abnormal volume reduction in sickle reticulocytes
Clinton H. Joiner, R. Kirk Rettig, Maorong Jiang, Mary Risinger, and Robert S. Franco
p.1728-1735
STEM CELLS IN HEMATOLOGY:
The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging
Melissa Dumble, Lynette Moore, Stuart M. Chambers, Hartmut Geiger, Gary Van Zant, Margaret A. Goodell, and Lawrence A. Donehower
p.1736-1742
SSEA-4 identifies mesenchymal stem cells from bone marrow
Eun J. Gang, Darko Bosnakovski, Camila A. Figueiredo, Jan W. Visser, and Rita C. R. Perlingeiro
p.1743-1751
TRANSFUSION MEDICINE:
Brief report Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model
Christopher C. Silliman, Brian R. Curtis, Patricia M. Kopko, Samina Y. Khan, Marguerite R. Kelher, Randy M. Schuller, Baindu Sannoh, and Daniel R. Ambruso
p.1752-1755
TRANSPLANTATION:
Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease
Yukimi Sakoda, Daigo Hashimoto, Shoji Asakura, Kengo Takeuchi, Mine Harada, Mitsune Tanimoto, and Takanori Teshima
p.1756-1764
Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor study
K. Scott Baker, Kirsten K. Ness, Julia Steinberger, Andrea Carter, Liton Francisco, Linda J. Burns, Charles Sklar, Stephen Forman, Daniel Weisdorf, James G. Gurney, and Smita Bhatia
p.1765-1772
B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-GAL–producing B-1 cells
Ichiro Shimizu, Toshiyasu Kawahara, Fabienne Haspot, Philip D. Bardwell, Michael C. Carroll, and Megan Sykes
p.1773-1781
The effects of imatinib mesylate treatment before allogeneic transplantation for chronic myeloid leukemia
Vivian G. Oehler, Ted Gooley, David S. Snyder, Laura Johnston, Allen Lin, Carrie C. Cummings, Su Chu, Ravi Bhatia, Stephen J. Forman, Robert S. Negrin, Frederick R. Appelbaum, and Jerald P. Radich
p.1782-1789
CORRESPONDENCE:
Imatinib concentrations in human milk
Carlo B. Gambacorti-Passerini, Lucia Tornaghi, Elena Marangon, Anna Franceschino, Enrico M. Pogliani, Maurizio D'Incalci, and Massimo Zucchetti
p.1790
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