INSIDE BLOOD:
Full clot retraction: running on mTOR
Michael C. Berndt and Robert K. Andrews
p.1791-1792
HTLV-IIb reduces HIV infection
Davide Zella
p.1792
Thrombospondin says no to NO
Themis R. Kyriakides
p.1793
Acquired hemophilia A: is more better?
Joan Cox Gill
p.1793-1794
Bone morphogenetic proteins go endothelial
Danny Huylebroeck
p.1794-1795
Will the real EPC please stand up?
Aernout Luttun and Catherine M. Verfaillie
p.1795-1796
Fast track to becoming a regulatory T cell: "trogocytosis" of immune-tolerogenic HLA-G
Heinz Wiendl
p.1796-1797
BLOOD WORK:
Beyond the wide blue sea
p.1799
PLENARY PAPERS:
Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals
Mervin C. Yoder, Laura E. Mead, Daniel Prater, Theresa R. Krier, Karim N. Mroueh, Fang Li, Rachel Krasich, Constance J. Temm, Josef T. Prchal, and David A. Ingram
p.1801-1809
PERSPECTIVE:
End points to establish the efficacy of new agents in the treatment of acute leukemia
Frederick R. Appelbaum, Daniel Rosenblum, Robert J. Arceci, William L. Carroll, Philip P. Breitfeld, Stephen J. Forman, Richard A. Larson, Stephanie J. Lee, Sharon B. Murphy, Susan O'Brien, Jerald Radich, Nancy S. Scher, Franklin O. Smith, Richard M. Stone, and Martin S. Tallman
p.1810-1816
REVIEW ARTICLES:
Neutrophil elastase in cyclic and severe congenital neutropenia
Marshall S. Horwitz, Zhijun Duan, Brice Korkmaz, Hu-Hui Lee, Matthew E. Mealiffe, and Stephen J. Salipante
p.1817-1824
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
Endolyn (CD164) modulates the CXCL12-mediated migration of umbilical cord blood CD133+ cells
Sinead Forde, Britt Jorgensen Tye, Sarah E. Newey, Maria Roubelakis, Jon Smythe, Colin P. McGuckin, Ruth Pettengell, and Suzanne M. Watt
p.1825-1833
Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor
Helena Stabile, Stefania Mitola, Emanuela Moroni, Mirella Belleri, Stefania Nicoli, Daniela Coltrini, Francesco Peri, Antonello Pessi, Laura Orsatti, Fabio Talamo, Vincent Castronovo, David Waltregny, Franco Cotelli, Domenico Ribatti, and Marco Presta
p.1834-1840
Noninfectious papilloma virus–like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27
J. Mohamad Fakruddin, Richard A. Lempicki, Robert J. Gorelick, Jun Yang, Joseph W. Adelsberger, Alfonso J. Garcia-Pineres, Ligia A. Pinto, H. Clifford Lane, and Tomozumi Imamichi
p.1841-1849
Postgenomic up-regulation of CCL3L1 expression in HTLV-2–infected persons curtails HIV-1 replication
Elisabetta Pilotti, Lisa Elviri, Elisa Vicenzi, Umberto Bertazzoni, Maria Carla Re, Sonia Allibardi, Guido Poli, and Claudio Casoli
p.1850-1856
CLINICAL TRIALS AND OBSERVATIONS:
The revised International Prognostic Index (R-IPI) is a better predictor of outcome than the standard IPI for patients with diffuse large B-cell lymphoma treated with R-CHOP
Laurie H. Sehn, Brian Berry, Mukesh Chhanabhai, Catherine Fitzgerald, Karamjit Gill, Paul Hoskins, Richard Klasa, Kerry J. Savage, Tamara Shenkier, Judy Sutherland, Randy D. Gascoyne, and Joseph M. Connors
p.1857-1861
Effect of genetic variations in platelet glycoproteins Ib and VI on the risk for coronary heart disease events in postmenopausal women taking hormone therapy
Paul F. Bray, Timothy D. Howard, Eric Vittinghoff, David C. Sane, and David M. Herrington
p.1862-1869
Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors' Organisation
Peter W. Collins, Sybil Hirsch, Trevor P. Baglin, Gerard Dolan, John Hanley, Michael Makris, David M. Keeling, Ri Liesner, Simon A. Brown, Charles R. M. Hay, and UK Haemophilia Centre Doctors' Organisation
p.1870-1877
Late cardiotoxicity after treatment for Hodgkin lymphoma
Berthe M. P. Aleman, Alexandra W. van den Belt-Dusebout, Marie L. De Bruin, Mars B. van 't Veer, Margreet H. A. Baaijens, Jan Paul de Boer, Augustinus A. M. Hart, Willem J. Klokman, Marianne A. Kuenen, Gabey M. Ouwens, Harry Bartelink, and Flora E. van Leeuwen
p.1878-1886
HEMATOPOIESIS:
ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes
Irina R. Matei, Rebecca A. Gladdy, Lauryl M. J. Nutter, Angelo Canty, Cynthia J. Guidos, and Jayne S. Danska
p.1887-1896
Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways
Olga S. Kustikova, Hartmut Geiger, Zhixiong Li, Martijn H. Brugman, Stuart M. Chambers, Chad A. Shaw, Karin Pike-Overzet, Dick de Ridder, Frank J. T. Staal, Gottfried von Keudell, Kerstin Cornils, Kalpana Jekumar Nattamai, Ute Modlich, Gerard Wagemaker, Margaret A. Goodell, Boris Fehse, and Christopher Baum
p.1897-1907
The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl–/– phenotype
Wan Y. I. Chan, George A. Follows, Georges Lacaud, John E. Pimanda, Josette-Renee Landry, Sarah Kinston, Kathy Knezevic, Sandie Piltz, Ian J. Donaldson, Laure Gambardella, Fred Sablitzky, Anthony R. Green, Valerie Kouskoff, and Berthold Göttgens
p.1908-1916
Ape1 regulates hematopoietic differentiation of embryonic stem cells through its redox functional domain
Gang-Ming Zou, Mei-Hua Luo, April Reed, Mark R. Kelley, and Mervin C. Yoder
p.1917-1922
Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cells
Shigeki Ito, Charlie R. Mantel, Myung-Kwan Han, Sunanda Basu, Seiji Fukuda, Scott Cooper, and Hal E. Broxmeyer
p.1923-1930
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
Active tissue factor pathway inhibitor is expressed on the surface of coated platelets
Susan A. Maroney, Sandra L. Haberichter, Paul Friese, Maureen L. Collins, Josephine P. Ferrel, George L. Dale, and Alan E. Mast
p.1931-1937
Tumor necrosis factor (TNF-) receptor-II is required for TNF-–induced leukocyte-endothelial interaction in vivo
Unni M. Chandrasekharan, Maria Siemionow, Murat Unsal, Lin Yang, Earl Poptic, Justin Bohn, Kagan Ozer, Zhongmin Zhou, Philip H. Howe, Marc Penn, and Paul E. DiCorleto
p.1938-1944.
Thrombospondin-1 limits ischemic tissue survival by inhibiting nitric oxide–mediated vascular smooth muscle relaxation
Jeff S. Isenberg, Fuminori Hyodo, Ken-Ichiro Matsumoto, Martin J. Romeo, Mones Abu-Asab, Maria Tsokos, Periannan Kuppusamy, David A. Wink, Murali C. Krishna, and David D. Roberts
p.1945-1952
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells
Laurent David, Christine Mallet, Sabine Mazerbourg, Jean-Jacques Feige, and Sabine Bailly
p.1953-1961
Cooperation between VEGF and ß3 integrin during cardiac vascular development
Sara M. Weis, Jeffrey N. Lindquist, Leo A. Barnes, Kimberly M. Lutu-Fuga, Jianhua Cui, Malcolm R. Wood, and David A. Cheresh
p.1962-1970
Human plasma fibrinogen is synthesized in the liver
Glenys A. Tennent, Stephen O. Brennan, Arie J. Stangou, John O'Grady, Philip N. Hawkins, and Mark B. Pepys
p.1971-1974
mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
Andrew S. Weyrich, Melvin M. Denis, Hansjorg Schwertz, Neal D. Tolley, Jason Foulks, Eliott Spencer, Larry W. Kraiss, Kurt H. Albertine, Thomas M. McIntyre, and Guy A. Zimmerman
p.1975-1983
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency
Angelina J. Lay, Deborah Donahue, Meng-Ju Tsai, and Francis J. Castellino
p.1984-1991
Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo
Toshihiko Nishimura, Timothy Myles, Adrian M. Piliposky, Peter N. Kao, Gerald J. Berry, and Lawrence L. K. Leung
p.1992-1997
Brief report ADAMTS13 and von Willebrand factor and the risk of myocardial infarction in men
Chan K. N. K. Chion, Carine J. M. Doggen, James T. B. Crawley, David A. Lane, and Frits R. Rosendaal
p.1998-2000
IMMUNOBIOLOGY:
Differential epitope mapping of antibodies to PDC-E2 in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation and primary biliary cirrhosis
Roberto Bellucci, Sabine Oertelt, Meagan Gallagher, Sigui Li, Emmanuel Zorn, Edie Weller, Fabrice Porcheray, Edwin P. Alyea, Robert J. Soiffer, Nikhil C. Munshi, M. Eric Gershwin, and Jerome Ritz
p.2001-2007
In vivo control of acute lymphoblastic leukemia by immunostimulatory CpG oligonucleotides
Hisaki Fujii, Jacqueline D. Trudeau, David T. Teachey, Jonathan D. Fish, Stephan A. Grupp, Kirk R. Schultz, and Gregor S. D. Reid
p.2008-2013
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells
Natasha K. Crellin, Rosa V. Garcia, and Megan K. Levings
p.2014-2022
IL-21 receptor signaling is integral to the development of Th2 effector responses in vivo
Anja Fröhlich, Benjamin J. Marsland, Ivo Sonderegger, Michael Kurrer, Martin R. Hodge, Nicola L. Harris, and Manfred Kopf
p.2023-2031
ZAP-70 enhances B-cell–receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells
Stefania Gobessi, Luca Laurenti, Pablo G. Longo, Simona Sica, Giuseppe Leone, and Dimitar G. Efremov
p.2032-2039
Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells
Joel LeMaoult, Julien Caumartin, Marina Daouya, Benoit Favier, Solene Le Rond, Alvaro Gonzalez, and Edgardo D. Carosella
p.2040-2048
Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients
Chun Fu Zheng, Ling Ling Ma, Gareth J. Jones, M. John Gill, Alan M. Krensky, Paul Kubes, and Christopher H. Mody
p.2049-2057
Galectin-1: a key effector of regulation mediated by CD4+CD25+ T cells
Marina I. Garín, Chung-Ching Chu, Dela Golshayan, Eva Cernuda-Morollón, Robin Wait, and Robert I. Lechler
p.2058-2065.
Gene expression patterns in blood leukocytes discriminate patients with acute infections
Octavio Ramilo, Windy Allman, Wendy Chung, Asuncion Mejias, Monica Ardura, Casey Glaser, Knut M. Wittkowski, Bernard Piqueras, Jacques Banchereau, A. Karolina Palucka, and Damien Chaussabel
p.2066-2077
Expansion of V1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressing UL-16–binding proteins
Silvia Catellani, Alessandro Poggi, Andrea Bruzzone, Patrizia Dadati, Jean Louis Ravetti, Marco Gobbi, and Maria Raffaella Zocchi
p.2078-2085
Brief report Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7
Angela Malaspina, Susan Moir, Doreen G. Chaitt, Catherine A. Rehm, Shyam Kottilil, Judith Falloon, and Anthony S. Fauci
p.2086-2088
NEOPLASIA:
4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4
Suk Hang Cheng, Margaret H. L. Ng, Kin Mang Lau, Herman S. Y. Liu, Joyce C. W. Chan, Angela B. Y. Hui, Kwok Wai Lo, Hua Jiang, Jian Hou, Raymond W. Chu, Wai Shan Wong, Natalie P. H. Chan,, and Ho Keung Ng
p.2089-2099
Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma
Christian Jakob, Karl Egerer, Peter Liebisch, Seval Türkmen, Ivana Zavrski, Ulrike Kuckelkorn, Ulrike Heider, Martin Kaiser, Claudia Fleissner, Jan Sterz, Lorenz Kleeberg, Eugen Feist, Gerd-R. Burmester, Peter-M. Kloetzel, and Orhan Sezer
p.2100-2105
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
Shmuel Yaccoby, Wen Ling, Fenghuang Zhan, Ronald Walker, Bart Barlogie, and John D. Shaughnessy, Jr
p.2106-2111
Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias
Ellen Weisberg, Laurie Catley, Renee D. Wright, Daisy Moreno, Lolita Banerji, Arghya Ray, Paul W. Manley, Juergen Mestan, Doriano Fabbro, Jingrui Jiang, Elizabeth Hall-Meyers, Linda Callahan, Jamie L. DellaGatta, Andrew L. Kung, and James D. Griffin
p.2112-2120
MEK blockade converts AML differentiating response to retinoids into extensive apoptosis
Michele Milella, Marina Konopleva, Cristina M. Precupanu, Yoko Tabe, Maria Rosaria Ricciardi, Chiara Gregorj, Steven J. Collins, Bing Z. Carter, Carmen D'Angelo, Maria Teresa Petrucci, Robin Foà, Francesco Cognetti, Agostino Tafuri, and Michael Andreeff
p.2121-2129
SDX-308, a nonsteroidal anti-inflammatory agent, inhibits NF-B activity, resulting in strong inhibition of osteoclast formation/activity and multiple myeloma cell growth
Rentian Feng, Gülsüm Anderson, Guozhi Xiao, Gary Elliott, Lorenzo Leoni, Markus Y. Mapara, G. David Roodman, and Suzanne Lentzsch
p.2130-2138
Enhanced natural-killer cell and erythropoietic activities in VEGF-A–overexpressing mice delay F-MuLV–induced erythroleukemia
David Cervi, Yuval Shaked, Mehran Haeri, Tatiana Usenko, Christina R. Lee, Jody J. Haigh, Andras Nagy, Robert S. Kerbel, Eitan Yefenof, and Yaacov Ben-David
p.2139-2146
Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation
Ying Wang, Dali Cai, Cornelia Brendel, Christine Barett, Philipp Erben, Paul W. Manley, Andreas Hochhaus, Andreas Neubauer, and Andreas Burchert
p.2147-2155
Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes
Laurence Lamant, Aurélien de Reyniès, Marie-Michèle Duplantier, David S. Rickman, Frédérique Sabourdy, Sylvie Giuriato, Laurence Brugières, Philippe Gaulard, Estelle Espinos, and Georges Delsol
p.2156-2164
Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
Sang-Hoon Sin, Debasmita Roy, Ling Wang, Michelle R. Staudt, Farnaz D. Fakhari, Dhavalkumar D. Patel, David Henry, William J. Harrington, Jr, Blossom A. Damania, and Dirk P. Dittmer
p.2165-2173
K1 protein of human herpesvirus 8 suppresses lymphoma cell Fas-mediated apoptosis
Suizhao Wang, Shu Wang, Hoyoung Maeng, Daniel P. Young, Om Prakash, Luis E. Fayad, Anas Younes, and Felipe Samaniego
p.2174-2182
Expression of the granzyme B inhibitor PI9 predicts outcome in nasal NK/T-cell lymphoma: results of a Western series of 48 patients treated with first-line polychemotherapy within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials
Céline Bossard, Karim Belhadj, Felix Reyes, Nadine Martin-Garcia, Françoise Berger, Jean Alain Kummer, Josette Brière, Anne-Catherine Baglin, Stéphane Cheze, Jacques Bosq, Vincent Ribrag, Christian Gisselbrecht, Nicolas Mounier, and Philippe Gaulard
p.2183-2189
Expression of a non–DNA-binding isoform of Helios induces T-cell lymphoma in mice
Zheng Zhang, C. Scott Swindle, John T. Bates, Rose Ko, Claudiu V. Cotta, and Christopher A. Klug
p.2190-2197
Brief report Respiratory tract infections and subsequent risk of chronic lymphocytic leukemia
Ola Landgren, Joshua S. Rapkin, Neil E. Caporaso, Lene Mellemkjaer, Gloria Gridley, Lynn R. Goldin, and Eric A. Engels
p.2198-2201
Brief report Novel activating JAK2 mutation in a patient with Down syndrome and B-cell precursor acute lymphoblastic leukemia
Sebastien Malinge, Raouf Ben-Abdelali, Catherine Settegrana, Isabelle Radford-Weiss, Marianne Debre, Kheira Beldjord, Elizabeth A. Macintyre, Jean-Luc Villeval, William Vainchenker, Roland Berger, Olivier A. Bernard, Eric Delabesse, and Virginie Penard-Lacronique
p.2202-2204
RED CELLS:
Evidence for the multimeric structure of ferroportin
Ivana De Domenico, Diane McVey Ward, Giovanni Musci, and Jerry Kaplan
p.2205-2209
Transcriptional interference among the murine ß-like globin genes
Xiao Hu, Susan Eszterhas, Nicolas Pallazzi, Eric E. Bouhassira, Jennifer Fields, Osamu Tanabe, Scott A. Gerber, Michael Bulger, James Douglas Engel, Mark Groudine, and Steven Fiering
p.2210-2216
Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum
Rowena E. Martin and Kiaran Kirk
p.2217-2224
TRANSPLANTATION:
Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease
Robert Zeiser, Vu H. Nguyen, Jing-Zhou Hou, Andreas Beilhack, Elizabeth Zambricki, Martin Buess, Christopher H. Contag, and Robert S. Negrin
p.2225-2233
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex
Moutih Rafei, Jian Hui Wu, Borhane Annabi, Laurence Lejeune, Moïra François, and Jacques Galipeau
p.2234-2242
Autologous hematopoietic stem cell transplantation in refractory celiac disease with aberrant T cells
Abdulbaqi Al-toma, Otto J. Visser, Hyacintha M. van Roessel, B. Mary E. von Blomberg, Wieke H. M. Verbeek, Petra E. T. Scholten, Gert J. Ossenkoppele, Peter C. Huijgens, and Chris J. J. Mulder
p.2243-2249
Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial
Héliton Spíndola Antunes, Alexandre Mello de Azevedo, Luiz Fernando da Silva Bouzas, Carlos Alberto Esteves Adão, Claudia Tereza Pinheiro, Renato Mayhe, Lucia Helena Pinheiro, Renato Azevedo, Valkiria D'Aiuto de Matos, Pedro Carvalho Rodrigues, Isabele Avila Small, Renato Amaro Zangaro, and Carlos Gil Ferreira
p.2250-2255
Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia
John E. Wagner, Mary Eapen, Margaret L. MacMillan, Richard E. Harris, Ricardo Pasquini, Farid Boulad, Mei-Jie Zhang, and Arleen D. Auerbach
p.2256-2262
CORRESPONDENCE:
Optimizing fusion transcript monitoring in CML
Mark Hertzberg and David McDonald
p.2263
Response: Reliability of PCR for BCR-ABL transcripts
Timothy Hughes, Susan Branford, and John M. Goldman
p.2263-2264
Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML
Martin Bornhäuser, Thomas Illmer, Markus Schaich, Silke Soucek, Gerhard Ehninger, and Christian Thiede, for the AML SHG 96 study group
p.2264-2265
Response: Still a need for more robust evidence that FLT3/ITD status should influence the decision to proceed to transplantation in AML patients
Rosemary E. Gale, Robert Hills, Keith Wheatley, Alan K. Burnett, and David C. Linch
p.2265
Metoclopramide treatment in DBA patients: no complete response in a French prospective study
Thierry M. Leblanc, Lydie Da Costa, Isabelle Marie, Pierre Demolis, and Gilbert Tchernia
p.2266-2267
Correction of the bleeding time in von Willebrand factor (VWF)–deficient mice using murine VWF
Peter J. Lenting, Philip G. de Groot, Simon F. De Meyer, Karen Vanhoorelbeke, Cynthia Pruss, David Lillicrap, Isabelle Marx, and Cécile V. Denis
p.2267-2268
ERRATUM:
Correction for Dou et al., Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery
p.1816
Correction for Kelly et al., CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells
p.1849
|
