INSIDE BLOOD:
A triple on AL amyloidosis, waiting for a home run
Geraldine P. Schechter
p. 391-392
A new mechanism for nitric oxide– and cGMP-mediated platelet inhibition
Xiaoping Du
p. 392-393
How complex is the platelet GP Ib complex?
Kenneth J. Clemetson
Blood 2007 109: 393-394
Platelets: tetherballs in thrombus formation
Bruce Furie
p. 394
Livin: a proapoptotic factor in ALL?
Ching-Hon Pui
p. 394-395
A "joint" statement on inhibitor-bypassing therapy
W. Keith Hoots
p. 395-396
MK-0457: a light at the end of the tunnel?
Giovanni Martinelli, Simona Soverini, Ilaria Iacobucci, and Michele Baccarani
Blood 2007 109: 396-397
PLENARY PAPERS:
Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia
John C. Byrd, Thomas S. Lin, James T. Dalton, Di Wu, Mitch A. Phelps, Beth Fischer, Mollie Moran, Kristie A. Blum, Brad Rovin, Michelle Brooker-McEldowney, Sarah Broering, Larry J. Schaaf, Amy J. Johnson, David M. Lucas, Nyla A. Heerema, Gerard Lozanski, Donn C. Young, Jose-Ramon Suarez, A. Dimitrios Colevas, and Michael R. Grever
p. 399-404
Combination chemoimmunotherapy with pentostatin, cyclophosphamide, and rituximab shows significant clinical activity with low accompanying toxicity in previously untreated B chronic lymphocytic leukemia
Neil E. Kay, Susan M. Geyer, Timothy G. Call, Tait D. Shanafelt, Clive S. Zent, Diane F. Jelinek, Renee Tschumper, Nancy D. Bone, Gordon W. Dewald, Thomas S. Lin, Nyla A. Heerema, Lisa Smith, Michael R. Grever, and John C. Byrd
p. 405-411
REVIEW ARTICLES:
Hematologic manifestations of celiac disease
Thorvardur R. Halfdanarson, Mark R. Litzow, and Joseph A. Murray
p.: 412-421
REVIEWS IN TRANSLATIONAL HEMATOLOGY:
Current concepts on the pathogenesis of the antiphospholipid syndrome
Bill Giannakopoulos, Freda Passam, Soheila Rahgozar, and Steven A. Krilis
p. 422-430
Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification?
Krzysztof Mrózek, Guido Marcucci, Peter Paschka, Susan P. Whitman, and Clara D. Bloomfield
p. 431-448
CHEMOKINES, CYTOKINES, AND INTERLEUKINS:
Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells
Takuwa Yasuda, Taku Kuwabara, Hideki Nakano, Kentaro Aritomi, Takashi Onodera, Martin Lipp, Yousuke Takahama, and Terutaka Kakiuchi
p.: 449-456
CLINICAL TRIALS AND OBSERVATIONS:
Safety and efficacy of risk-adapted cyclophosphamide, thalidomide, and dexamethasone in systemic AL amyloidosis
Ashutosh D. Wechalekar, Hugh J. B. Goodman, Helen J. Lachmann, Mark Offer, Philip N. Hawkins, and Julian D. Gillmore
p. 457-464
The activity of lenalidomide with or without dexamethasone in patients with primary systemic amyloidosis
Angela Dispenzieri, Martha Q. Lacy, Steven R. Zeldenrust, Suzanne R. Hayman, Shaji K. Kumar, Susan M. Geyer, John A. Lust, Jacob B. Allred, Thomas E. Witzig, S. Vincent Rajkumar, Philip R. Greipp, Stephen J. Russell, Brian Kabat, and Morie A. Gertz
p. 465-470
Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia
Jaewon Choi, Yu Kyeong Hwang, Ki Woong Sung, Soo Hyun Lee, Keon Hee Yoo, Hye Lim Jung, Hong Hoe Koo, Hee-Jin Kim, Hyong Jin Kang, Hee Young Shin, and Hyo Seop Ahn
p. 471-477
Intravascular large B-cell lymphoma (IVLBCL): a clinicopathologic study of 96 cases with special reference to the immunophenotypic heterogeneity of CD5
Takuhei Murase, Motoko Yamaguchi, Ritsuro Suzuki, Masataka Okamoto, Yumiko Sato, Jun-ichi Tamaru, Masaru Kojima, Ikuo Miura, Naoyoshi Mori, Tadashi Yoshino, and Shigeo Nakamura
p.478-485
Early FDG-PET assessment in combination with clinical risk scores determines prognosis in recurring lymphoma
Bart W. Schot, Josée M. Zijlstra, Wim J. Sluiter, Gustaaf W. van Imhoff, Jan Pruim, Willem Vaalburg, and Edo Vellenga
p. 486-491
Lenalidomide and dexamethasone in the treatment of AL amyloidosis: results of a phase 2 trial
Vaishali Sanchorawala, Daniel G. Wright, Michael Rosenzweig, Kathleen T. Finn, Salli Fennessey, Jerome B. Zeldis, Martha Skinner, and David C. Seldin
p. 492-496
Brief report Dasatinib (BMS-354825) is active in Philadelphia chromosome–positive chronic myelogenous leukemia after imatinib and nilotinib (AMN107) therapy failure
Alfonso Quintas-Cardama, Hagop Kantarjian, Dan Jones, Claude Nicaise, Susan O'Brien, Francis Giles, Moshe Talpaz, and Jorge Cortes
p. 497-499
Brief report MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation
Francis J. Giles, Jorge Cortes, Dan Jones, Donald Bergstrom, Hagop Kantarjian, and Steven J. Freedman
p. 500-502
GENE THERAPY:
SCID and trisomy 8 mosaicism: a case report
Barbara C. Engel, Greg M. Podsakoff, Joanna L. Ireland, E. Monika Smogorzewska, Denise A. Carbonaro, Kathy Wilson, Ami Shah, Neena Kapoor, Mirna Sweeney, Mark Borchert, Gay M. Crooks, Kenneth I. Weinberg, Robertson Parkman, Howard M. Rosenblatt, Shi-Qi Wu, Michael S. Hershfield, Fabio Candotti, and Donald B. Kohn
p. 503-506
HEMATOPOIESIS:
Regulation of dendritic-cell differentiation by bone marrow stroma via different Notch ligands
Pingyan Cheng, Yulia Nefedova, Cesar A. Corzo, and Dmitry I. Gabrilovich
p. 507-515
Smad1 expands the hemangioblast population within a limited developmental window
Brian T. Zafonte, Susanna Liu, Macarena Lynch-Kattman, Ingrid Torregroza, Luke Benvenuto, Marion Kennedy, Gordon Keller, and Todd Evans
p. 516-523
Functional characterization of natural telomerase mutations found in patients with hematologic disorders
Zhong-Tao Xin, Adam D. Beauchamp, Rodrigo T. Calado, Jennifer W. Bradford, Joshua A. Regal, Aarthi Shenoy, Yuying Liang, Peter M. Lansdorp, Neal S. Young, and Hinh Ly
p. 524-532
The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration
Lara Rossi, Rossella Manfredini, Francesco Bertolini, Davide Ferrari, Miriam Fogli, Roberta Zini, Simona Salati, Valentina Salvestrini, Sara Gulinelli, Elena Adinolfi, Sergio Ferrari, Francesco Di Virgilio, Michele Baccarani, and Roberto M. Lemoli
p. 533-542.
Brief report Low rhodamine 123 retention identifies long-term human hematopoietic stem cells within the Lin–CD34+CD38– population
Joby L. McKenzie, Katsuto Takenaka, Olga I. Gan, Monica Doedens, and John E. Dick
p. 543-545
HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY:
A randomized comparison of bypassing agents in hemophilia complicated by an inhibitor: the FEIBA NovoSeven Comparative (FENOC) Study
Jan Astermark, Sharyne M. Donfield, Donna M. DiMichele, Alessandro Gringeri, Steven A. Gilbert, Jennifer Waters, and Erik Berntorp, for the FENOC Study Group
p. 546-551
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation
Melanie Antl, Marie-Luise von Brühl, Christina Eiglsperger, Matthias Werner, Ildiko Konrad, Thomas Kocher, Matthias Wilm, Franz Hofmann, Steffen Massberg, and Jens Schlossmann
p. 552-559
Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis
Jack L. Arbiser, Tweeny Kau, Martha Konar, Krishna Narra, Ramani Ramchandran, Scott A. Summers, Chris J. Vlahos, Keqiang Ye, Betsy N. Perry, William Matter, Anthony Fischl, James Cook, Pamela A. Silver, Jenny Bain, Philip Cohen, David Whitmire, Scott Furness, Baskaran Govindarajan, and J. Phillip Bowen
p. 560-565
Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation
Mhairi J. Maxwell, Erik Westein, Warwick S. Nesbitt, Simon Giuliano, Sacha M. Dopheide, and Shaun P. Jackson
p. 566-576
Tissue factor deficiency and PAR-1 deficiency are protective against renal ischemia reperfusion injury
Jacob Sevastos, Sean E. Kennedy, Darren R. Davis, Melissa Sam, Philip W. Peake, John A. Charlesworth, Nigel Mackman, and Jonathan H. Erlich
p. 577-583
The THAP–zinc finger protein THAP1 regulates endothelial cell proliferation through modulation of pRB/E2F cell-cycle target genes
Corinne Cayrol, Chrystelle Lacroix, Catherine Mathe, Vincent Ecochard, Michele Ceribelli, Emilie Loreau, Vladimir Lazar, Philippe Dessen, Roberto Mantovani, Luc Aguilar, and Jean-Philippe Girard
p. 584-594
Activation of IIbß3 is a sufficient but also an imperative prerequisite for activation of 2ß1 on platelets
Gerlinde R. Van de Walle, Anne Schoolmeester, Brecht F. Iserbyt, Judith M. E. M. Cosemans, Johan W. M. Heemskerk, Marc F. Hoylaerts, Alan Nurden, Karen Vanhoorelbeke, and Hans Deckmyn
p. 595-602
Glycoprotein Ib forms disulfide bonds with 2 glycoprotein Ibß subunits in the resting platelet
Shi-Zhong Luo, Xi Mo, Vahid Afshar-Kharghan, Sankaranarayanan Srinivasan, José A. López, and Renhao Li
p. 603-609
Brief report VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors
Suryasarathi Dasgupta, Yohann Repessé, Jagadeesh Bayry, Ana-Maria Navarrete, Bharath Wootla, Sandrine Delignat, Theano Irinopoulou, Caroline Kamaté, Jean-Marie Saint-Remy, Marc Jacquemin, Peter J. Lenting, Annie Borel-Derlon, Srinivas V. Kaveri, and Sébastien Lacroix-Desmazes
p. 610-612
Brief report Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium
Kiichiro Yano, Daniel Gale, Steffen Massberg, Pavan K. Cheruvu, Rita Monahan-Earley, Ellen S. Morgan, David Haig, Ulrich H. von Andrian, Ann M. Dvorak, and William C. Aird
p. 613-615
Brief report Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase
Antonija Jurak Begonja, Jörg Geiger, Natalia Rukoyatkina, Steffen Rauchfuss, Stepan Gambaryan, and Ulrich Walter
p. 616-618
IMMUNOBIOLOGY:
Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-ß
Jiangao Zhu, Jennifer Martinez, Xiaopei Huang, and Yiping Yang
p. 619-625
Regulation of dendritic cell migration and adaptive immune response by leukotriene B4 receptors: a role for LTB4 in up-regulation of CCR7 expression and function
Annalisa Del Prete, Wen-Hai Shao, Stefania Mitola, Giuseppe Santoro, Silvano Sozzani, and Bodduluri Haribabu
p. 626-631
Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop
Marco Cosentino, Anna Maria Fietta, Marco Ferrari, Emanuela Rasini, Raffaella Bombelli, Elena Carcano, Federica Saporiti, Federica Meloni, Franca Marino, and Sergio Lecchini
p. 632-642
Differentiation of CD1a– and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPAR
Peter Gogolak, Bence Rethi, Istvan Szatmari, Arpad Lanyi, Balazs Dezso, Laszlo Nagy, and Eva Rajnavolgyi
p. 643-652
Apoptotic cells induce Mer tyrosine kinase–dependent blockade of NF-B activation in dendritic cells
Pradip Sen, Mark A. Wallet, Zuoan Yi, Yingsu Huang, Michael Henderson, Clayton E. Mathews, H. Shelton Earp, Glenn Matsushima, Albert S. Baldwin, Jr, and Roland M. Tisch
p. 653-660
Active MAC-1 (CD11b/CD18) on DCs inhibits full T-cell activation
Georg Varga, Sandra Balkow, Martin K. Wild, Andrea Stadtbaeumer, Mathias Krummen, Tobias Rothoeft, Tetsuya Higuchi, Stefan Beissert, Klaus Wethmar, Karin Scharffetter-Kochanek, Dietmar Vestweber, and Stephan Grabbe
p. 661-669
Brief report Increased surveillance of cells in mitosis by human NK cells suggests a novel strategy for limiting tumor growth and viral replication
Esther N. M. Nolte–'t Hoen, Catarina R. Almeida, Nadia R. Cohen, Shlomo Nedvetzki, Helen Yarwood, and Daniel M. Davis
p. 670-673
NEOPLASIA:
Characterization of a progenitor cell population in childhood T-cell acute lymphoblastic leukemia
Charlotte V. Cox, Hannah M. Martin, Pamela R. Kearns, Paul Virgo, Roger S. Evely, and Allison Blair
p. 674-682
Promoter SNPs in G1/S checkpoint regulators and their impact on the susceptibility to childhood leukemia
Jasmine Healy, Hélène Bélanger, Patrick Beaulieu, Mathieu Larivière, Damian Labuda, and Daniel Sinnett
p. 683-692
Human mesenchymal stem cells isolated from bone marrow and lymphoid organs support tumor B-cell growth: role of stromal cells in follicular lymphoma pathogenesis
Patricia Amé-Thomas, Hélène Maby-El Hajjami, Céline Monvoisin, Rachel Jean, Delphine Monnier, Sylvie Caulet-Maugendre, Thierry Guillaudeux, Thierry Lamy, Thierry Fest, and Karin Tarte
p. 693-702
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-B pathway
Tomoyuki Endo, Mitsufumi Nishio, Thomas Enzler, Howard B. Cottam, Tetsuya Fukuda, Danelle F. James, Michael Karin, and Thomas J. Kipps
p. 703-710
Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts
Consuelo Gajate and Faustino Mollinedo
p. 711-719
STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90 and ß in multiple myeloma cells, which critically contribute to tumor-cell survival
Manik Chatterjee, Sarika Jain, Thorsten Stühmer, Mindaugas Andrulis, Ute Ungethüm, Ralf-Jürgen Kuban, Heike Lorentz, Kurt Bommert, Max Topp, Doris Krämer, Hans Konrad Müller-Hermelink, Hermann Einsele, Axel Greiner, and Ralf C. Bargou
p. 720-728
Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL
April Chiu, Weifeng Xu, Bing He, Stacey R. Dillon, Jane A. Gross, Eric Sievers, Xugang Qiao, Paul Santini, Elizabeth Hyjek, Joong-won Lee, Ethel Cesarman, Amy Chadburn, Daniel M. Knowles, and Andrea Cerutti
p. 729-739
Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells
Jordy Leung, Annie Pang, Wai-Hung Yuen, Yok-Lam Kwong, and Eric W. C. Tse
p. 740-746
KLF4 suppresses transformation of pre-B cells by ABL oncogenes
Michael G. Kharas, Isharat Yusuf, Vanessa M. Scarfone, Vincent W. Yang, Julia A. Segre, Claudia S. Huettner, and David A. Fruman
p. 747-755
Mitochondrial DNA sequence variation in single cells from leukemia patients
Yong-Gang Yao, Yoji Ogasawara, Sachiko Kajigaya, Jeffrey J. Molldrem, Roberto P. Falcão, Maria-Carolina Pintão, J. Philip McCoy, Jr, Edgar Gil Rizzatti, and Neal S. Young
p. 756-762
Rce1 deficiency accelerates the development of K-RAS–induced myeloproliferative disease
Annika M. Wahlstrom, Briony A. Cutts, Christin Karlsson, Karin M. E. Andersson, Meng Liu, Anna-Karin M. Sjogren, Birgitta Swolin, Stephen G. Young, and Martin O. Bergo
p. 763-768
Aberrant transcriptional regulation of the MLL fusion partner EEN by AML1-ETO and its implication in leukemogenesis
Li-Heng Ma, Han Liu, Hui Xiong, Bing Chen, Xiao-Wei Zhang, Yue-Ying Wang, Huang-Ying Le, Qiu-Hua Huang, Qing-Hua Zhang, Bo-Liang Li, Zhu Chen, and Sai-Juan Chen
p. 769-777
SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl
Jing Chen, Wen-Mei Yu, Hanako Daino, Hal E. Broxmeyer, Brian J. Druker, and Cheng-Kui Qu
p. 778-785
CXCR4 is a prognostic marker in acute myelogenous leukemia
Anke C. Spoo, Michael Lübbert, William G. Wierda, and Jan A. Burger
p. 786-791
Brief report Regulation of the Arf tumor suppressor in Eµ-Myc transgenic mice: longitudinal study of Myc-induced lymphomagenesis
David Bertwistle and Charles J. Sherr
p.792-794
RED CELLS:
Dynamic posttranscriptional regulation of -globin gene expression in vivo
Zhenning He and J. Eric Russell
p 795-801
Red-cell ICAM-4 is a ligand for the monocyte/macrophage integrin CD11c/CD18: characterization of the binding sites on ICAM-4
Eveliina Ihanus, Liisa M. Uotila, Anne Toivanen, Minna Varis, and Carl G. Gahmberg
p. 802-810
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice
Saïd Lyoumi, Marie Abitbol, Valérie Andrieu, Dominique Henin, Elodie Robert, Caroline Schmitt, Laurent Gouya, Hubert de Verneuil, Jean-Charles Deybach, Xavier Montagutelli, Carole Beaumont, and Hervé Puy
p. 811-818
TRANSPLANTATION:
Rapid quantification of naive alloreactive T cells by TNF- production and correlation with allograft rejection in mice
Michael A. Brehm, Julie Mangada, Thomas G. Markees, Todd Pearson, Keith A. Daniels, Thomas B. Thornley, Raymond M. Welsh, Aldo A. Rossini, and Dale L. Greiner
p. 819-826
In vitro–expanded donor alloantigen–specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance
Dela Golshayan, Shuiping Jiang, Julia Tsang, Marina I. Garin, Christian Mottet, and Robert I. Lechler
p. 827-835
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47
Hui Wang, Jon VerHalen, Maria Lucia Madariaga, Shuanglin Xiang, Shumei Wang, Ping Lan, Per-Arne Oldenborg, Megan Sykes, and Yong-Guang Yang
Blood 2007 109: 836-842
CORRESPONDENCE:
BCL-6 and rituximab in diffuse large B-cell lymphoma: where are we?
Kieron Dunleavy, R. Eric Davis, Ola Landgren, Louis M. Staudt, and Wyndham H. Wilson
p. 843-844
Response: Outcomes with R-CHOP in DLBCL leave ample room for improvement
Jane N. Winter, Edie A. Weller, Sandra J. Horning, and Randy D. Gascoyne
p. 844
Response: BCL6 and outcome in diffuse large B-cell lymphoma: a work in progress
Craig H. Moskowitz, Paul A. Hamlin, and Andrew D. Zelenetz
p. 845
Hepatitis C virus and alanine aminotransferase kinetics following B-lymphocyte depletion with rituximab: evidence for a significant role of humoral immunity in the control of viremia in chronic HCV liver disease
Gerond Lake-Bakaar, Lynn Dustin, Jane McKeating, Kimberley Newton, Victoria Freeman, and Simon D.W. Frost
p. 845-846
Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb
Shaun P. Jackson, Susan Cranmer, Pierre Mangin, and Yuping Yuan
p. 846-847
Response: Establishing the physiological significance in vivo answers the challenge of unraveling the details of GPIb-initiated signal transduction
Junling Liu, Malinda E. C. Fitzgerald, Michael C. Berndt, Carl W. Jackson, and T. Kent Gartner
p. 847-848
Response: Is there a physiologically relevant experimental model system to study GP1b-mediated signaling in platelets?
Satya P. Kunapuli
p. 109: 848
ERRATA:
Erratum in Jeong et al. HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity.
p.411 |
